Evidence map›Paper›PMID 24696721›Full record

ReviewInternational journal of clinical and experimental pathology2014

Mantle cell lymphoma with in situ or mantle zone growth pattern: a study of five cases and review of literature.

Peihong Hsu, Tianyu Yang, Silvat Sheikh-Fayyaz, Judith Brody, Jela Bandovic, Sarma Roy, Jordan Laser, Jonathan E Kolitz, Craig Devoe, Xinmin Zhang

Abstract readCase ReportsReview
PubMed Full text at PMC
In one paragraph

Review in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. An overlapping case of in situ mantle cell neoplasia and leukemic non-nodal mantle cell lymphoma.Journal of clinical and experimental hematopathology : JCEH · 2020
    Article
  4. Article
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Peihong HsuDepartment of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Tianyu YangDepartment of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Silvat Sheikh-FayyazDepartment of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Judith BrodyDepartment of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Jela BandovicDepartment of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Sarma RoyDepartment of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Jordan LaserDepartment of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Jonathan E KolitzDepartment of Internal Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Craig DevoeDepartment of Internal Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.
Xinmin ZhangDepartment of Pathology and Laboratory Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine Lake Success, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present two rare cases of in situ mantle cell lymphoma ("in situ MCL") and three cases of MCL with mantle zone growth pattern (MCL-MZGP). The patients include four males and one female, with a median age of 66 years (range, 52 to 86 years). Two present with isolated lymphadenopathy and three with multiple lymphadenopathy. At presentation, the complete blood count (CBC) and serum lactate dehydrogenase (LDH) are normal in all cases. Histologic examination reveals an in situ pattern in two cases and a mantle zone growth pattern in three cases. The staging bone marrow biopsies show minimal involvement by lymphoma in one case and no morphologic evidence of lymphoma in four cases. All cases are positive for cyclin D1, including two with typical MCL phenotype and three with CD5-negativity. Four out of five cases express kappa light chain. FISH study for t(11;14) is performed in three cases, of which one is positive and two are inconclusive. For four patients with a median follow-up of 38 months, three are in clinical remission and one has persistent disease. In conclusion, the "in situ MCL" is associated with incidental finding, indolent clinical course and lower tumor burden. The predominant usage of kappa light chain and frequent CD5-negativity observed in our cases are unusual. We review the clinical and laboratory features of "in situ MCL" cases in the literature.

Indexed as

AgedAged, 80 and overFemaleHumansLymphoma, Mantle-CellMaleMiddle Agedin situ mantle cell lymphomaMantle cell lymphomat(11;14)

Identifiers

PMID24696721
PMCPMC3971307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.