ArticleInternational journal of endocrinology2014
Negative influence of a long-term high-fat diet on murine bone architecture.
Article in International journal of endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Protective Effects of Kelulut Honey on Bone Strength and Marrow Adiposity in Rats Fed with High-Carbohydrate High-Fat Diet.International journal of medical sciences · 2025Article
- Saturated fatty acids negatively affect musculoskeletal tissuesMatrix biology plus · 2024Article
- Effect of Dietary Geranylgeraniol and Green Tea Polyphenols on Glucose Homeostasis, Bone Turnover Biomarkers, and Bone Microstructure in Obese Mice.International journal of molecular sciences · 2023Article
- Obesity and Bone: A Complex Relationship.International journal of molecular sciences · 2021Review
- Molecular Interactions between Dietary Lipids and Bone Tissue during Aging.International journal of molecular sciences · 2021Review
- Adiponectin signalling in bone homeostasis, with age and in disease.Bone research · 2021Review
- Article
- Diet-induced obesity suppresses cortical bone accrual by a neuropeptide Y-dependent mechanism.International journal of obesity (2005) · 2018Article
- High Fructose and High Fat Exert Different Effects on Changes in Trabecular Bone Micro-structure.The journal of nutrition, health & aging · 2018Article
- Effects of metabolic syndrome on bone mineral density, histomorphometry and remodelling markers in male rats.PloS one · 2018Article
- [Research advances of fluid bio-mechanics in bone].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2017Review
- Changes in bone macro- and microstructure in diabetic obese mice revealed by high resolution microfocus X-ray computed tomography.Scientific reports · 2016Article
- Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model.Molecular and cellular endocrinology · 2016Article
- Methodological considerations when studying the skeletal response to glucose intolerance using the diet-induced obesity model.BoneKEy reports · 2016Article
- Changes in Skeletal Integrity and Marrow Adiposity during High-Fat Diet and after Weight Loss.Frontiers in endocrinology · 2016Article
- Long-Term Administration of High-Fat Diet Corrects Abnormal Bone Remodeling in the Tibiae of Interleukin-6-Deficient Mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A correlation between obesity and bone metabolism is strongly assumed because adipocytes and osteoblasts originate from the same precursor cells and their differentiation is conversely regulated by the same factors. It is controversially discussed if obesity protects bone or leads to loss of bone mass. Thus, the aim of the present study was to investigate the influence of diet-induced mild obesity (11% increased body weight compared to control) on bone microstructure in mice. Four-week-old male C57BL/6J mice received a high-fat diet (HFD, 60% kcal from fat) and were analyzed by means of dual X-ray absorptiometry, histological methods, real-time RT-PCR, and transmission electron microscopy in comparison to control animals (10% kcal from fat). The cancellous bone mass, collagen 1α1 expression, amount of osteoid, and cohesion of cells via cell-to-cell contacts decreased in HFD mice whereas the bone mineral density and the amount of osteoblasts and osteoclasts were not modified. The amount of apoptotic osteocytes was increased in HFD mice in comparison to controls. We conclude that moderately increased body weight does not protect bone architecture from age-dependent degeneration. By contrast, bone microstructure is negatively affected and reduced maintenance of cell-cell contacts may be one of the underlying mechanisms.
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Registered trials
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