ArticleAdvances in pharmacological sciences2014
Prophylactic Role of Averrhoa carambola (Star Fruit) Extract against Chemically Induced Hepatocellular Carcinoma in Swiss Albino Mice.
Article in Advances in pharmacological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Ethanolic Extract ofPharmaceutics · 2024Article
- Nutritional and medicinal properties of Star fruit (Food science & nutrition · 2021Review
- Traditional Uses, Phytochemical Constituents and Pharmacological Properties ofFrontiers in pharmacology · 2021Review
- Hepatoprotective Plants from Bangladesh: A Biophytochemical Review and Future Prospect.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- In vivo the antioxidative extract ofFood science and biotechnology · 2020Article
- Antihyperlipidemic and Antioxidant Effects ofBiomedicines · 2019Article
- Chemomodulatory Potential of Flaxseed Oil Against DMBA/Croton Oil-Induced Skin Carcinogenesis in Mice.Integrative cancer therapies · 2016Article
- Recombinant soluble gp130 protein reduces DEN-induced primary hepatocellular carcinoma in mice.Scientific reports · 2016Article
- Effects of 20 Selected Fruits on Ethanol Metabolism: Potential Health Benefits and Harmful Impacts.International journal of environmental research and public health · 2016Article
- The Epidemiological Investigation on the Risk Factors of Hepatocellular Carcinoma: A Case-Control Study in Southeast China.Medicine · 2016Article
- Nutritional, Medicinal and Toxicological Attributes of Star-Fruits (Averrhoa carambola L.): A Review.Bioinformation · 2016Review
- Thai Fruits Exhibit Antioxidant Activity and Induction of Antioxidant Enzymes in HEK-293 Cells.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Chemoprevention of chemical-induced skin cancer by Panax ginseng root extract.Journal of ginseng research · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver cancer remains one of the severe lethal malignancies worldwide and hepatocellular carcinoma (HCC) is the most common form. The current study was designed to evaluate the prophylactic role of the fruit of Averrhoa carambola (star fruit or Kamrak) on diethylnitrosamine- (DENA-) induced (15 mg/kg b.wt.; single i.p. injection) and CCl4-promoted (1.6 g/kg b.wt. in corn oil thrice a week for 24 weeks) liver cancer in Swiss albino mice. Administration of ACE was made orally at a dose of 25 mg/kg b.wt/day for 5 consecutive days and it was withdrawn 48 hrs before the first administration of DENA (preinitiational stage). CCl4 was given after 2 weeks of DENA administration. A cent percent tumor incidence was noted in carcinogen treated animals while ACE administration resulted in a considerable reduction in tumor incidence, tumor yield, and tumor burden. Further, ACE treatment brings out a significant reduction in lipid peroxidation (P < 0.001) along with an elevation in the activities of enzymatic antioxidants (superoxide dismutase, P < 0.001, and catalase, P < 0.001), nonenzymatic antioxidant (reduced glutathione, P < 0.001), and total proteins (P < 0.001) when compared to the carcinogen treated control. These results demonstrate that ACE prevents the DENA/CCl4 induced adverse physical and biochemical alterations during hepatic carcinogenesis in mice. This study suggests the prophylactic role of Averrhoa carambola against hepatocellular carcinoma in mice; therefore, it could be employed for the further screening as a good chemopreventive natural supplement against cancer.
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Registered trials
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