Trial reportTheScientificWorldJournal2014
Biochemical characterization of early osteoarthritis in the ankle.
Trial report in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Clinical Trial and In Vitro Study for the Role of Cartilage and Synovia in Acute Articular Infection.Mediators of inflammation · 2015Trial
- Molecular-biomechanical phenotyping of ankle osteoarthritis: from synovial biomarkers to weight-bearing digital signatures.Frontiers in medicine · 2026Review
- Potential Roles of Inflammation on Post-Traumatic Osteoarthritis of the Ankle.International journal of molecular sciences · 2024Review
- Ankle osteoarthritis: comprehensive review and treatment algorithm proposal.EFORT open reviews · 2022Review
- Bone marrow aspirate concentrate and scaffold for osteochondral lesions of the talus in ankle osteoarthritis: satisfactory clinical outcome at 10 years.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Article
- Elevation of Inflammatory Cytokines and Proteins after Intra-Articular Ankle Fracture: A Cross-Sectional Study of 47 Ankle Fracture Patients.Mediators of inflammation · 2021Article
- NF-κB Phosphorylation Inhibition Prevents Articular Cartilage Degradation in Osteoarthritis Rats via 2-Aminoquinoline.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- AMD3100 Attenuates Post-Traumatic Osteoarthritis by Maintaining Transforming Growth Factor-β1-Induced Expression of Tissue Inhibitor of Metalloproteinase-3Frontiers in pharmacology · 2019Article
- Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis.Molecular medicine reports · 2018Article
- Establishment of rat ankle post-traumatic osteoarthritis model induced by malleolus fracture.BMC musculoskeletal disorders · 2017Article
- Osteoarthritis in Football.Cartilage · 2017Article
- Correlation between Gene Expression and Osteoarthritis Progression in Human.International journal of molecular sciences · 2016Article
- Prospective clinical trial of patients who underwent ankle arthroscopy with articular diseases to match clinical and radiological scores with intra-articular cytokines.International orthopaedics · 2015Article
- Prospective Clinical Trial for Septic Arthritis: Cartilage Degradation and Inflammation Are Associated with Upregulation of Cartilage Metabolites.Mediators of inflammationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeReliable data about in vivo regulation of cytokines in early ankle osteoarthritis (OA) are still missing.
methods49 patients with a mean age of 33 ± 14 years undergoing an arthroscopy of the ankle with different stages of chronic OA were prospectively included in a clinical trial. Lavage fluids were analyzed by ELISA. Additionally, clinical parameters and scores (FFI, CFSS, and AOFAS) were evaluated and supplemented by the Kellgren Lawrence Score (KLS) and the ankle osteoarthritis scoring system (AOSS).
resultsICRS grading of cartilage damage, previous operations, and duration of complains were strong indicators for OA progress and showed correlations to age, clinical scores, validated KLS, and AOSS (P < 0.04). Systemic and intraarticular inflammatory parameters were low in all patients. Biochemically, aggrecan and BMP-7 positively indicated OA with statistically significant associations with duration of symptoms, FFI, AOFAS, and KLS (P < 0.04). In contrast, BMP-2 levels showed statistically significant negative correlations to aggrecan or BMP-7 concentrations, which is in line with the negative association with ICRS score and KLS and the positive correlation with FFI (P < 0.03).
conclusionsWe were able to identify different key markers of OA in the ankle as aggrecan, BMP-7, and BMP-2, offering starting points for new ways in diagnostics and interventional strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.