ArticleGenome biology and evolution2014
The elusive nature of adaptive mitochondrial DNA evolution of an arctic lineage prone to frequent introgression.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 127 citations in OpenAlex.
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- Unidirectional Mitochondrial Introgression Despite Limited Nuclear Admixture in North American Red-Backed Voles,Ecology and evolution · 2025Article
- Influence of life-history traits on mitochondrial DNA substitution rates exceeds that of metabolic rates in teleost fishes.Current zoology · 2025Article
- Repeated Mitochondrial Capture With Limited Genomic Introgression in a Lizard Group.Molecular ecology · 2025Article
- Mitogenome of Neolissochilus pnar, the largest cavernicolous species of Mahseer.Scientific reports · 2025Article
- The first complete mitochondrial genome of Sumatran striped rabbit Nesolagus netscheri (Schlegel, 1880), and its phylogenetic relationship with other Leporidae.Scientific reports · 2025Article
- The complete mitochondrial DNA sequence of theMitochondrial DNA. Part B, Resources · 2025Article
- The complete mitochondrial genome of Poncelet's giant rat (Mitochondrial DNA. Part B, Resources · 2025Article
- Museum Skins Enable Identification of Introgression Associated with Cytonuclear Discordance.Systematic biology · 2024Article
- Evolutionary characteristics of the mitochondrial NADH dehydrogenase subunit 6 gene in some populations of four sympatric Mustela species (Mustelidae, Mammalia) from central Europe.Molecular biology reports · 2024Article
- The mitochondrial genome sequence of Manchurian Hare (Mitochondrial DNA. Part B, Resources · 2024Article
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- Genetic characteristics of complete mtDNA genome sequence of Indonesian local rabbit (Oryctolagus cuniculus).Journal, genetic engineering & biotechnology · 2023Article
- Purifying selection leads to low protein diversity of the mitochondrial cyt b gene in avian malaria parasites.BMC ecology and evolution · 2023Article
- Ancient DNA of the Don-Hares Assumes the Existence of Two Distinct Mitochondrial Clades in Northeast Asia.Genes · 2023Article
- The complete mitochondrial genome of the 'Zacatuche' Volcano rabbit (Romerolagus diazi), an endemic and endangered species from the Volcanic Belt of Central Mexico.Molecular biology reports · 2022Article
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- Hybridization Dynamics and Extensive Introgression in the Daphnia longispina Species Complex: New Insights from a High-Quality Daphnia galeata Reference Genome.Genome biology and evolution · 2021Article
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Authors and funding
6 authors at 3 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondria play a fundamental role in cellular metabolism, being responsible for most of the energy production of the cell in the oxidative phosphorylation (OXPHOS) pathway. Mitochondrial DNA (mtDNA) encodes for key components of this process, but its direct role in adaptation remains far from understood. Hares (Lepus spp.) are privileged models to study the impact of natural selection on mitogenomic evolution because 1) species are adapted to contrasting environments, including arctic, with different metabolic pressures, and 2) mtDNA introgression from arctic into temperate species is widespread. Here, we analyzed the sequences of 11 complete mitogenomes (ten newly obtained) of hares of temperate and arctic origins (including two of arctic origin introgressed into temperate species). The analysis of patterns of codon substitutions along the reconstructed phylogeny showed evidence for positive selection in several codons in genes of the OXPHOS complexes, most notably affecting the arctic lineage. However, using theoretical models, no predictable effect of these differences was found on the structure and physicochemical properties of the encoded proteins, suggesting that the focus of selection may lie on complex interactions with nuclear encoded peptides. Also, a cloverleaf structure was detected in the control region only from the arctic mtDNA lineage, which may influence mtDNA replication and transcription. These results suggest that adaptation impacted the evolution of hare mtDNA and may have influenced the occurrence and consequences of the many reported cases of massive mtDNA introgression. However, the origin of adaptation remains elusive.
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