ArticleIn vitro cellular & developmental biology. Animal2014
RyR channel-mediated increase of cytosolic free calcium level signals cyclin B1 degradation during abortive spontaneous egg activation in rat.
Article in In vitro cellular & developmental biology. Animal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Egg Overactivation-An Overlooked Phenomenon of Gamete Physiology.International journal of molecular sciences · 2025Review
- Spontaneous Overactivation ofInternational journal of molecular sciences · 2024Article
- The role of oxidative stress in ovarian aging: a review.Journal of ovarian research · 2022Review
- Meiotic Instability Generates a Pathological Condition in Mammalian Ovum.Stem cell reviews and reports · 2021Review
- Necroptosis in stressed ovary.Journal of biomedical science · 2019Review
- Biochemical Hallmarks of Oxidative Stress-Induced Overactivation ofBioMed research international · 2019Article
- Postovulatory cell death: why eggs die via apoptosis in biological species with external fertilization.The Journal of reproduction and development · 2018Review
- Increased level of reactive oxygen species persuades postovulatory aging-mediated spontaneous egg activation in rat eggs cultured in vitro.In vitro cellular & developmental biology. Animal · 2016Article
- Nitric oxide signals postovulatory aging-induced abortive spontaneous egg activation in rats.Redox report : communications in free radical research · 2015Article
- Morphological, cellular and molecular changes during postovulatory egg aging in mammals.Journal of biomedical science · 2015Review
- Reactive Oxygen Species Generation and Use of Antioxidants duringInternational journal of fertility & sterilityReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In few mammalian species including rat, post-ovulatory aging induces abortive spontaneous egg activation (SEA), which is morphologically characterized by exit from metaphase-II (M-II) arrest. A possibility exists that the RyR channel-mediated insufficient increase of cytosolic free Ca(2+) level could be one of the causes for post-ovulatory aging-induced abortive SEA. To test this possibility, eggs collected after 17 h post-hCG surge were cultured with or without various concentrations of nifedipine (NF), ruthenium red (RR), and KN-93 for 3 h in vitro. Morphological changes characteristic of abortive SEA, cytosolic free Ca(2+) level, cyclin B1 level, and meiotic status were analyzed. Data of the present study indicate that NF and RR inhibited post-ovulatory aging-induced abortive SEA in a concentration-dependent manner. Further, RR protected against RyR channel as well as caffeine-mediated increase of cytosolic free Ca(2+) level. In addition, KN-93 inhibited post-ovulatory aging-induced abortive SEA in a concentration-dependent manner. An increase of cytosolic free Ca(2+) level was associated with a reduction of cyclin B1 level during post-ovulatory aging-induced abortive SEA. These data indirectly suggest the involvement of RyR channels in the increase of cytosolic free Ca(2+) level. The increased cytosolic free Ca(2+) level triggers cyclin B1 degradation possibly through CaMK-II activity during post-ovulatory aging-induced abortive SEA in rat eggs cultured in vitro.
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