SynthesisJournal of nephrology2014
Metabolic syndrome and nephrolithiasis: a systematic review and meta-analysis of the scientific evidence.
Synthesis in Journal of nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Nutrients, vitamins, probiotics and herbal products: an update of their role in urolithogenesis.Urolithiasis · 2020Pooled it
- Kidney stones may increase the risk of coronary heart disease and stroke: A PRISMA-Compliant meta-analysis.Medicine · 2017Pooled it
- Article
- Brown adipose tissue detection using positron emission tomography could help reduce urolithiasis risk.Urolithiasis · 2025Article
- Effect of gout and diabetic kidney disease on renal cancer development in Korea.Clinical kidney journal · 2024Article
- Scoping review of recent evidence on the management of pediatric urolithiasis: summary of meta-analyses, systematic reviews and relevant randomized controlled trials.Pediatric surgery international · 2022Article
- The Occurrence of Nephrolithiasis in Gout Patients: A Longitudinal Follow-Up Study Using a National Health Screening Cohort.Life (Basel, Switzerland) · 2022Article
- Article
- Idiopathic Osteoporosis and Nephrolithiasis: Two Sides of the Same Coin?International journal of molecular sciences · 2020Review
- Relationship between Kidney Stone Disease and Arterial Stiffness in a Taiwanese Population.Journal of clinical medicine · 2020Article
- Article
- Article
- Heritable traits that contribute to nephrolithiasis.Urolithiasis · 2019Review
- Metabolic syndrome and the composition of urinary calculi: is there any relation?Central European journal of urology · 2019Article
- Article
- Urinary Stone Disease and Cardiovascular Disease Risk in a Rural Chinese Population.Kidney international reports · 2017Article
- Kidney stones diseases and glycaemic statuses: focus on the latest clinical evidences.Urolithiasis · 2017Review
- The Risk of Nephrolithiasis Among Patients With Ankylosing Spondylitis: a Population-Based Cohort Study.Archives of rheumatology · 2016Article
- Metabolic Syndrome and Nephrolithiasis Risk: Should the Medical Management of Nephrolithiasis Include the Treatment of Metabolic Syndrome?Reviews in urology · 2015Article
- Association between dietary pattern and metabolic disorders in children and adolescents with urolithiasis.Jornal de pediatriaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metabolic syndrome is a cluster of cardiometabolic alterations at least partly dependent on reduced insulin sensitivity and hyperinsulinemia that can have several renal implications. A systematic review and meta-analysis of studies available in the international literature in English language demonstrates that the metabolic syndrome occurrence is associated with a significantly higher prevalence of nephrolithiasis (odds ratio 1.29, 95% confidence intervals: 1.11-1.51). The pathophysiological bases of this association are currently not completely understood, however. Potential pathogenetic links between the two conditions include metabolic factors that promote insulin resistance as well as stone formation in urine, environmental factors such as diet, oxidative stress and inflammation, and molecular changes impacting the transport of some analytes in urine. Metabolic syndrome-related nephrolithiasis shows peculiar clinical and biochemical characteristics and should be considered a multifactorial systemic disorder needing a multidisciplinary approach for adequate prevention and management in pediatric and adult age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.