ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2014
A genetic basis for infectious mononucleosis: evidence from a family study of hospitalized cases in Denmark.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Steroids for symptom control in infectious mononucleosis.The Cochrane database of systematic reviews · 2015Pooled it
- Early virological and immunological events in asymptomatic Epstein-Barr virus infection in African children.PLoS pathogens · 2015Trial
- Distinct EBV-Associated Phenotypes Due to a Novel Homozygous Missense Variant inbioRxiv : the preprint server for biology · 2026Article
- Associations between past infectious mononucleosis diagnosis and 47 inflammatory and vascular stress biomarkers.Scientific reports · 2025Article
- Risk of infectious mononucleosis is not associated with prior infection morbidity.Frontiers in epidemiology · 2025Article
- HLA-E-restricted immune responses are crucial for the control of EBV infections and the prevention of PTLD.Blood · 2023Article
- Review
- Infectious mononucleosis, immune genotypes, and non-Hodgkin lymphoma (NHL): an InterLymph Consortium study.Cancer causes & control : CCC · 2020Article
- Article
- Familial aggregation of tonsillectomy in early childhood and adolescence.Clinical epidemiology · 2018Article
- Asymptomatic Primary Infection with Epstein-Barr Virus: Observations on Young Adult Cases.Journal of virology · 2017Observational
- Cytomegalovirus, Epstein-Barr virus and varicella zoster virus infection in the first two years of life: a cohort study in Bradford, UK.BMC infectious diseases · 2017Article
- Host genetics of Epstein-Barr virus infection, latency and disease.Reviews in medical virology · 2015Review
- Infectious mononucleosis.Clinical & translational immunology · 2015Review
- Infectious Mononucleosis.Current topics in microbiology and immunology · 2015Review
- Editorial commentary: Genetics and infectious mononucleosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCircumstantial evidence from genome-wide association and family studies of various Epstein-Barr virus-associated diseases suggests a substantial genetic component in infectious mononucleosis (IM) etiology. However, familial aggregation of IM has scarcely been studied.
methodsWe used data from the Danish Civil Registration System and the Danish National Hospital Discharge Register to study rate ratios of IM in a cohort of 2 823 583 Danish children born between 1971 and 2011. Specifically, we investigated the risk of IM in twins and in first-, second-, and third-degree relatives of patients with IM. In the analyses, IM was defined as a diagnosis of IM in a hospital contact. Effects of contagion between family members were dealt with by excluding follow-up time the first year after the occurrence of IM in a relative.
resultsA total of 16 870 cases of IM were observed during 40.4 million person-years of follow-up from 1977 to 2011. The rate ratios and the associated 95% confidence intervals were 9.3 (3.0-29) in same-sex twins, 3.0 (2.6-3.5) in siblings, 1.9 (1.6-2.2) in children, 1.4 (1.3-1.6) in second-degree relatives, and 1.0 (0.9-1.2) in third-degree relatives of IM patients. The rate ratios were very similar for IM in children (aged 0-6 years) and older children/adolescents (aged 7-19 years).
conclusionsWe found evidence of familial aggregation of IM that warrants genome-wide association studies on IM disease etiology, especially to examine commonalities with causal pathways in other Epstein-Barr virus-related diseases.
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