Trial reportAIDS and behavior2015
Individualised motivational counselling to enhance adherence to antiretroviral therapy is not superior to didactic counselling in South African patients: findings of the CAPRISA 058 randomised controlled trial.
Trial report in AIDS and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00408642 (An Enhanced Adherence Support Programme for HAART), which is not on this map. Cited by 18 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Enhanced Adherence Support Programme for HAART
Who cites it
18 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Effectiveness of health education in improving treatment adherence among patients with chronic communicable diseases: A systematic review and meta-analysis.Tropical medicine & international health : TM & IH · 2025Pooled it
- Intervention strategies to improve adherence to treatment for selected chronic conditions in sub-Saharan Africa: a systematic review.Journal of the International AIDS Society · 2024Pooled it
- Psychosocial Interventions to Promote Undetectable HIV Viral Loads: A Systematic Review of Randomized Clinical Trials.AIDS and behavior · 2022Pooled it
- Motivational Interviewing in Ethnic Populations.Journal of immigrant and minority health · 2020Pooled it
- Non-specialist psychosocial support interventions for women living with HIV: A systematic review.AIDS care · 2017Pooled it
- Specification of implementation interventions to address the cascade of HIV care and treatment in resource-limited settings: a systematic review.Implementation science : IS · 2017Pooled it
- Pooled it
- Integrating prevention interventions for people living with HIV into care and treatment programs: a systematic review of the evidence.Journal of acquired immune deficiency syndromes (1999) · 2015Pooled it
- Personal Approach to Treatment Choices for HIV (PATCH): Randomized Controlled Trial of a Brief Motivational Enhancement Intervention to Improve Medication Adherence in Persons with HIV.AIDS and behavior · 2020Trial
- Experiences of support by unsuppressed adolescents living with HIV and their caregivers in Windhoek, Namibia: a qualitative study.Frontiers in public health · 2024Article
- Quality of TB care among people living with HIV: Gaps and solutions.Journal of clinical tuberculosis and other mycobacterial diseases · 2019Review
- Long-term adherence to antiretroviral therapy in a South African adult patient cohort: a retrospective study.BMC infectious diseases · 2019Article
- Loss to follow-up from antiretroviral therapy clinics: A systematic review and meta-analysis of published studies in South Africa from 2011 to 2015.Southern African journal of HIV medicine · 2019Article
- Availability of HIV services along the continuum of HIV testing, care and treatment in Ghana.BMC health services research · 2018Article
- A Framework for Health Communication Across the HIV Treatment Continuum.Journal of acquired immune deficiency syndromes (1999) · 2017Review
- A qualitative study of patient motivation to adhere to combination antiretroviral therapy in South Africa.AIDS patient care and STDs · 2015Article
- Outcomes from the implementation of a counselling model supporting rapid antiretroviral treatment initiation in a primary healthcare clinic in Khayelitsha, South Africa.Southern African journal of HIV medicine · 2015Article
- Implementation of a Psychosocial Support Intervention for Adolescents on Antiretroviral Treatment: Challenges and Experiences from Ehlanzeni District, South Africa.Journal of the International Association of Providers of AIDS CareArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Concerns that standard didactic adherence counselling may be inadequate to maximise antiretroviral therapy (ART) adherence led us to evaluate more intensive individualised motivational adherence counselling. We randomised 297 HIV-positive ART-naïve patients in Durban, South Africa, to receive either didactic counselling, prior to ART initiation (n = 150), or an intensive motivational adherence intervention after initiating ART (n = 147). Study arms were similar for age (mean 35.8 years), sex (43.1 % male), CD4+ cell count (median 121.5 cells/μl) and viral load (median 119,000 copies/ml). Virologic suppression at 9 months was achieved in 89.8 % of didactic and 87.9 % of motivational counselling participants (risk ratio [RR] 0.98, 95 % confidence interval [CI] 0.90-1.07, p = 0.62). 82.9 % of didactic and 79.5 % of motivational counselling participants achieved >95 % adherence by pill count at 6 months (RR 0.96, 95 % CI 0.85-1.09, p = 0.51). Participants receiving intensive motivational counselling did not achieve higher treatment adherence or virological suppression than those receiving routinely provided didactic adherence counselling. These data are reassuring that less resource intensive didactic counselling was adequate for excellent treatment outcomes in this setting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.