ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2015
Prognostic impact of expression and methylation status of DENN/MADD domain-containing protein 2D in gastric cancer.
Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 51 citations in OpenAlex.
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- Identification of Signature Genes Associated With Invasiveness and the Construction of a Prognostic Model That Predicts the Overall Survival of Bladder Cancer.Frontiers in genetics · 2021Article
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- A novel dual-marker expression panel for easy and accurate risk stratification of patients with gastric cancer.Cancer medicine · 2018Article
- Integrated multigene expression panel to prognosticate patients with gastric cancer.Oncotarget · 2018Article
- Expression of regulatory factor X1 can predict the prognosis of breast cancer.Oncology letters · 2017Article
- GPR155 Serves as a Predictive Biomarker for Hematogenous Metastasis in Patients with Gastric Cancer.Scientific reports · 2017Article
- Molecular mechanisms of peritoneal dissemination in gastric cancer.World journal of gastroenterology · 2016Review
- Effect of urokinase-type plasminogen activator system in gastric cancer with peritoneal metastasis.Oncology letters · 2016Article
- Nutritional predictors for postoperative short-term and long-term outcomes of patients with gastric cancer.Medicine · 2016Observational
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- NRAGE promotes the malignant phenotype of hepatocellular carcinoma.Oncology letters · 2016Article
- Downregulation of miR-522 suppresses proliferation and metastasis of non-small cell lung cancer cells by directly targeting DENN/MADD domain containing 2D.Scientific reports · 2016Article
- Advances in Understanding How Heavy Metal Pollution Triggers Gastric Cancer.BioMed research international · 2016Review
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18 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with advanced gastric cancer (GC) have an adverse prognosis even after curative resection. Development of novel diagnostic and therapeutic approaches for GC is urgently required.
methodsThe expression and methylation status of DENN/MADD domain-containing protein 2D (DENND2D), a member of the membrane trafficking proteins, were evaluated in 12 GC cell lines and 112 pairs of surgical specimens. Subgroup analysis based on tumor differentiation, location, and morphology was also performed. Expression and distribution of DENND2D protein were determined by immunohistochemistry.
resultsThe majority of GC cell lines (75%) and tissues (79%) showed reduced expression of DENND2D mRNA compared with noncancerous gastric tissues. GC tissues showed a significantly lower mean expression level of mRNA and a higher frequency of promoter hypermethylation of DENND2D than corresponding noncancerous tissues. No significant differences in DENND2D mRNA expression and methylation status were found between GC subtypes categorized by tumor differentiation, location, and morphology. The expression patterns of DENND2D protein were confirmed to be consistent with those of DENND2D mRNA. Downregulation of DENND2D mRNA in GC tissues was significantly associated with factors related to more advanced GC and subsequent adverse prognosis. Among 72 patients who underwent R0 resection, downregulation of DENND2D mRNA in GC tissues was an independent prognostic factor and associated with early recurrence.
conclusionsOur results suggested that DENND2D is a putative tumor suppressor gene regulated by promoter hypermethylation in GC. Downregulation of DENND2D can serve as a novel tumor biomarker to predict progression and early recurrence of all types of GC.
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