Evidence map›Paper›PMID 24695963›Full record

ArticleChemistry letters2014

Insights into Protein Allostery in the CsoR/RcnR Family of Transcriptional Repressors.

Khadine A Higgins, David Giedroc

Open access · bronzeAbstract read
In one paragraph

Article in Chemistry letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Regulation of a nickel tolerance operon conserved inApplied and environmental microbiology · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. The role of transcriptional regulators in metal ion homeostasis ofFrontiers in cellular and infection microbiology · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. The requirement for cobalt in vitamin BBiochimica et biophysica acta. Molecular cell research · 2021
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Complexation of the nickel and cobalt transcriptional regulator RcnR with DNA.Acta crystallographica. Section F, Structural biology communications · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Khadine A HigginsDepartment of Chemistry, Indiana University, 212 S. Hawthorne Drive, Bloomington, IN 47405, USA.
David GiedrocDepartment of Chemistry, Indiana University, 212 S. Hawthorne Drive, Bloomington, IN 47405, USA.
Indiana University · US

Funding

ZINC COORDINATION AND REGULATION OF ZINC METALLOPROTEINSR01GM042569 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI GIEDROC, DAVID P. · 1996 to 2015
$4.9M
New mechanisms of sulfur sensing and trafficking in Staphylococcus aureus.R01GM097225 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI GIEDROC, DAVID P. · 2011 to 2014
$1.1M
NIGMS NIH HHS R01 GM042569NIGMS NIH HHS R01 GM097225
6 · The paper itself

Abstract

CsoR/RcnR transcriptional repressors adopt a disc-shaped, all α-helical dimer of dimers tetrameric architecture, with a four-helix bundle the key structural feature of the dimer. Individual members of this large family of repressors coordinate Cu(I) or Ni(II)/Co(II) or perform cysteine sulfur chemistry in mitigating the effects of metal or metabolite toxicity, respectively. Here we highlight recent insights into the functional diversity of this fascinating family of repressors.

Identifiers

PMID24695963
PMCPMC3970791
OpenAlexW2087730360

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.