Evidence map›Paper›PMID 24695898›Full record

ArticleThe American journal of clinical nutrition2014

Life-course determinants of bone mass in young adults from a transitional rural community in India: the Andhra Pradesh Children and Parents Study (APCAPS).

Mika Matsuzaki, Hannah Kuper, Bharati Kulkarni, K V Radhakrishna, Heli Viljakainen, Amy E Taylor, Ruth Sullivan, Liza Bowen, Jon H Tobias, George B Ploubidis and 6 more

Open access · hybridAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 3 countries.

Mika MatsuzakiFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
Hannah KuperFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
Bharati KulkarniFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
K V RadhakrishnaFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
Heli ViljakainenFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
Amy E TaylorFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
Ruth SullivanFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
Liza BowenFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
Jon H TobiasFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
George B PloubidisFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
Jonathan C WellsFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
Dorairaj PrabhakaranFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
George Davey SmithFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
Shah EbrahimFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
Yoav Ben-ShlomoFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
Sanjay KinraFrom the Departments of Non-communicable Disease Epidemiology (MM, RS, SE, and SK), the Department of Medical Statistics (GBP), and Clinical Research (HK), London School of Hygiene and Tropical Medicine, London, United Kingdom; the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia (BK); the National Institute of Nutrition, Hyderabad, India (BK and KVR); the Musculoskeletal Research Unit, School of Clinical Sciences (HV and JHT) and the School of Social and Community Medicine (AET, YB-S, and GDS), University of Bristol, Bristol, United Kingdom; St George's University, London, United Kingdom (LB); the Childhood Nutrition Research Centre, UCL Institute of Child Health, London, United Kingdom (JCW); the Centre for Chronic Disease Control, New Delhi, India (DP); and the South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India (SE).
University of London · GB

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
Medical Research Council MC_UU_12013/1NCATS NIH HHS UL1 TR001425Wellcome Trust 084674
6 · The paper itself

Abstract

backgroundUndernutrition and physical inactivity are both associated with lower bone mass.

objectiveThis study aimed to investigate the combined effects of early-life undernutrition and urbanized lifestyles in later life on bone mass accrual in young adults from a rural community in India that is undergoing rapid socioeconomic development.

designThis was a prospective cohort study of participants of the Hyderabad Nutrition Trial (1987-1990), which offered balanced protein-calorie supplementation to pregnant women and preschool children younger than 6 y in the intervention villages. The 2009-2010 follow-up study collected data on current anthropometric measures, bone mineral density (BMD) measured by dual-energy X-ray absorptiometry, blood samples, diet, physical activity, and living standards of the trial participants (n = 1446, aged 18-23 y).

resultsParticipants were generally lean and had low BMD [mean hip BMD: 0.83 (women), 0.95 (men) g/cm²; lumbar spine: 0.86 (women), 0.93 (men) g/cm²]. In models adjusted for current risk factors, no strong evidence of a positive association was found between BMD and early-life supplementation. On the other hand, current lean mass and weight-bearing physical activity were positively associated with BMD. No strong evidence of an association was found between BMD and current serum 25-hydroxyvitamin D or dietary intake of calcium, protein, or calories.

conclusionsCurrent lean mass and weight-bearing physical activity were more important determinants of bone mass than was early-life undernutrition in this population. In transitional rural communities from low-income countries, promotion of physical activity may help to mitigate any potential adverse effects of early nutritional disadvantage.

Indexed as

AgingBone DensityBone RemodelingRural HealthSocial ChangeAdolescentAdultBone DevelopmentCohort StudiesDeveloping CountriesFemaleFollow-Up StudiesHumansIndiaMaleMotor Activity

Identifiers

PMID24695898
PMCPMC4021785
OpenAlexW2098995691

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.