Evidence map›Paper›PMID 24695809›Full record

ArticleWorld journal of gastroenterology2014

Protective effects of intravenous anesthetics on kidney tissue in obstructive jaundice.

Sinan Hatipoglu, Huseyin Yildiz, Ertan Bulbuloglu, Ismail Coskuner, Ergul Belge Kurutas, Filiz Hatipoglu, Harun Ciralik, Mehmet Sait Berhuni

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sinan HatipogluSinan Hatipoglu, Department of General Surgery Unit, School of Medicine, Adiyaman University, 02040 Adiyaman, Turkey.
Huseyin YildizSinan Hatipoglu, Department of General Surgery Unit, School of Medicine, Adiyaman University, 02040 Adiyaman, Turkey.
Ertan BulbulogluSinan Hatipoglu, Department of General Surgery Unit, School of Medicine, Adiyaman University, 02040 Adiyaman, Turkey.
Ismail CoskunerSinan Hatipoglu, Department of General Surgery Unit, School of Medicine, Adiyaman University, 02040 Adiyaman, Turkey.
Ergul Belge KurutasSinan Hatipoglu, Department of General Surgery Unit, School of Medicine, Adiyaman University, 02040 Adiyaman, Turkey.
Filiz HatipogluSinan Hatipoglu, Department of General Surgery Unit, School of Medicine, Adiyaman University, 02040 Adiyaman, Turkey.
Harun CiralikSinan Hatipoglu, Department of General Surgery Unit, School of Medicine, Adiyaman University, 02040 Adiyaman, Turkey.
Mehmet Sait BerhuniSinan Hatipoglu, Department of General Surgery Unit, School of Medicine, Adiyaman University, 02040 Adiyaman, Turkey.
Adıyaman University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the protective effects on kidney tissue of frequently used intravenous anesthetics (ketamine, propofol, thiopental, and fentanyl) in rats with obstructive jaundice.

methodsThere is an increased incidence of postoperative acute renal failure in patients with obstructive jaundice. Thirty-two Wistar-albino rats were randomly divided into four equal groups. Laparatomy was performed on each animal in the four groups and common bile ducts were ligated and severed on day 0. After 7 d, laparotomy was again performed using ketamine, propofol, thiopental, or fentanyl anesthesia whose antioxidative properties are well known in oxidative stress in a rat liver model of obstructive jaundice. After 2 h, the rats were sacrificed. Renal tissue specimens were analyzed for catalase, superoxide dismutase and malondialdehyde enzymes activities. All values are expressed as the mean ± SD. P values less than 0.05 were considered statistically significant.

resultsAll animals survived without complications until the end of the study. Enlargement in the bile duct and obstructive jaundice were observed in all rats. Catalase was found to be significantly lower in the fentanyl group than in the ketamine (P = 0.039), propofol (P = 0.012), and thiopental (P = 0.001) groups. Superoxide dismutase activities were similar in all groups (P > 0.05). Malondialdehyde was found to be significantly lower in the ketamine group than in the propofol (P = 0.028), thiopental (P = 0.002) and fentanyl (P = 0.005) groups. Malondialdehyde was also lower in the fentanyl group than in the thiopental group (P = 0.001). The results showed that obstructive jaundice sensitizes renal tissue to damage under the different anesthetics.

conclusionAmong the agents tested, ketamine and propofol generated the least amount of oxidative stres on renal tissues in this rat model of obstructive jaundice created by common bile duct ligation. The importance of free radical injury in renal tissue in obstructive jaundice under different intravenous anesthetics during hepatobiliary and liver transplant surgery should be considered for prevention of postoperative acute renal failure.

Indexed as

Administration, IntravenousAnesthetics, IntravenousAnimalsAntioxidantsCatalaseFentanylJaundice, ObstructiveKetamineKidneyMaleMalondialdehydeOxidative StressPropofolRatsRats, WistarSuperoxide DismutaseAnesthetics, IntravenousAntioxidantsCatalaseFentanylKetamineMalondialdehydePropofolSuperoxide DismutaseThiopentalIntravenous anestheticsObstructive jaundiceOxidative stressPostoperative acute renal failureRenal tissue damage

Identifiers

PMID24695809
PMCPMC3964402
OpenAlexW2039165801

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.