Evidence map›Paper›PMID 24695774›Full record

ArticleClinical and vaccine immunology : CVI2014

Lymphoproliferative and gamma interferon responses to stress-regulated Mycobacterium avium subsp. paratuberculosis recombinant proteins.

Ratna B Gurung, Douglas J Begg, Auriol C Purdie, Kumudika de Silva, John P Bannantine, Richard J Whittington

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Interferon-γ Response ofFrontiers in veterinary science · 2021
    Article
  3. Early Detection ofFrontiers in veterinary science · 2021
    Article
  4. Review
  5. Positive Correlation between IP-10 and IFN-BioMed research international · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ratna B GurungFaculty of Veterinary Science, University of Sydney, Camden, NSW, Australia.
Douglas J BeggFaculty of Veterinary Science, University of Sydney, Camden, NSW, Australia.
Auriol C PurdieFaculty of Veterinary Science, University of Sydney, Camden, NSW, Australia.
Kumudika de SilvaFaculty of Veterinary Science, University of Sydney, Camden, NSW, Australia.
John P BannantineBacterial Diseases of Livestock Research Unit, USDA ARS National Animal Disease Center, Ames, Iowa, USA.
Richard J WhittingtonFaculty of Veterinary Science, University of Sydney, Camden, NSW, Australia richard.whittington@sydney.edu.au.
University of Sydney · AUNational Animal Disease Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Johne's disease in ruminants is a chronic infection of the intestines caused by Mycobacterium avium subsp. paratuberculosis. An important strategy to control disease is early detection, and a potentially efficient method for early detection is measurement of cell-mediated immune responses developed by the host in response to exposure or infection. One method is to measure lymphoproliferation and cytokine release from the host cells when exposed to the organism or parts of the organism. In this study, 10 recombinant M. avium subsp. paratuberculosis proteins known to be upregulated under in vitro stress conditions were evaluated by examining their ability to evoke memory as a result of exposure by vaccination or oral challenge with live Mycobacterium avium subsp. paratuberculosis. Out of 10 proteins, MAP2698c was found to induce higher cell-mediated immune responses in vaccinated and challenged sheep in comparison to healthy controls. The findings suggest that not all stress-regulated proteins have the diagnostic potential to detect cell-mediated immune responses in ovine paratuberculosis.

Indexed as

AnimalsBacterial ProteinsCell ProliferationEarly DiagnosisFlow CytometryHeat-Shock ProteinsImmunity, CellularInterferon-gammaLymphocyte ActivationLymphocytesMycobacterium avium subsp. paratuberculosisParatuberculosisRecombinant ProteinsSheepSheep DiseasesBacterial ProteinsHeat-Shock ProteinsInterferon-gammaRecombinant Proteins

Identifiers

PMID24695774
PMCPMC4054239
OpenAlexW2108980784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.