Evidence map›Paper›PMID 24695758›Full record

ArticlePloS one2014

A prospective study of the prevalence of tuberculosis and bacteraemia in Bangladeshi children with severe malnutrition and pneumonia including an evaluation of Xpert MTB/RIF assay.

Mohammod Jobayer Chisti, Stephen M Graham, Trevor Duke, Tahmeed Ahmed, Hasan Ashraf, Abu Syed Golam Faruque, Sophie La Vincente, Sayera Banu, Rubhana Raqib, Mohammed Abdus Salam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 6 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 6 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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  4. Screening tests for active pulmonary tuberculosis in children.The Cochrane database of systematic reviews · 2021
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  19. Diagnosis of paediatric TB using XpertThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Mohammod Jobayer ChistiInternational Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Centre for International Child Health, The University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia.
Stephen M GrahamCentre for International Child Health, The University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia; International Union Against Tuberculosis and Lung Disease, Paris, France.
Trevor DukeCentre for International Child Health, The University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia.
Tahmeed AhmedInternational Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Hasan AshrafInternational Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Abu Syed Golam FaruqueInternational Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Sophie La VincenteCentre for International Child Health, The University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia.
Sayera BanuInternational Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Rubhana RaqibInternational Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Mohammed Abdus SalamInternational Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
International Centre for Diarrhoeal Disease Research · BDRoyal Children's Hospital · AUInternational Union Against Tuberculosis and Lung Disease · FRMurdoch Children's Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere malnutrition is a risk factor for pneumonia due to a wide range of pathogens but aetiological data are limited and the role of Mycobacterium tuberculosis is uncertain.

methodsWe prospectively investigated severely malnourished young children (<5 years) with radiological pneumonia admitted over a 15-month period. Investigations included blood culture, sputa for microscopy and mycobacterial culture. Xpert MTB/RIF assay was introduced during the study. Study children were followed for 12 weeks following their discharge from the hospital.

results405 eligible children were enrolled, with a median age of 10 months. Bacterial pathogens were isolated from blood culture in 18 (4.4%) children, of which 72% were Gram negatives. Tuberculosis was confirmed microbiologically in 7% (27/396) of children that provided sputum - 10 by culture, 21 by Xpert MTB/RIF assay, and 4 by both tests. The diagnostic yield from induced sputum was 6% compared to 3.5% from gastric aspirate. Sixty (16%) additional children had tuberculosis diagnosed clinically that was not microbiologically confirmed. Most confirmed tuberculosis cases did not have a positive contact history or positive tuberculin test. The sensitivity and specificity of Xpert MTB/RIF assay compared to culture was 67% (95% CI: 24-94) and 92% (95% CI: 87-95) respectively. Overall case-fatality rate was 17% and half of the deaths occurred in home following discharge from the hospital. CONCLUSION AND SIGNIFICANCE: TB was common in severely malnourished Bangladeshi children with pneumonia. X-pert MTB/RIF assay provided higher case detection rate compared to sputum microscopy and culture. The high mortality among the study children underscores the need for further research aimed at improved case detection and management for better outcomes.

Indexed as

BacteremiaBangladeshChild, PreschoolComorbidityFemaleHumansInfantMaleMalnutritionMolecular Diagnostic TechniquesPneumoniaPrevalenceProspective StudiesSensitivity and SpecificitySputumTuberculosis

Identifiers

PMID24695758
PMCPMC3973596
OpenAlexW2079431949

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.