ArticleBone & joint research2014
Animal models of cartilage repair.
Article in Bone & joint research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meniscectomy-induced osteoarthritis in the sheep model for the investigation of therapeutic strategies: a systematic review.International orthopaedics · 2020Pooled it
- Large Animal Models of Meniscus Repair and Regeneration: A Systematic Review of the State of the Field.Tissue engineering. Part C, Methods · 2017Pooled it
- Limited Added Effect of Proline-Rich P6 Peptide to Cross-Linked Hyaluronic Acid After Partial Lateral Meniscectomy in Sheep.Smart medicine · 2026Article
- Comparison of biologic hip preservation versus total hip arthroplasty in a preclinical canine model.Journal of hip preservation surgery · 2026Article
- Implantation and Analysis of a Biphasic Bioinspired Osteochondral Chitosan Construct in a Large Animal Model.ACS biomaterials science & engineering · 2026Article
- A hybrid repair strategy for full-thickness cartilage defects: Long-term experimental study in eight horses.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Integrative cartilage repair using acellular allografts for engineered structure and surface lubrication in vivo.NPJ Regenerative medicine · 2024Article
- A bioactive supramolecular and covalent polymer scaffold for cartilage repair in a sheep model.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Effect of Blood on Synovial Joint Tissues: Potential Role of Ferroptosis.Applied sciences (Basel, Switzerland) · 2024Article
- Plasma and synovial fluid extracellular vesicles display altered microRNA profiles in horses with naturally occurring post-traumatic osteoarthritis: an exploratory study.Journal of the American Veterinary Medical Association · 2024Article
- Knee osteoarthritis: A review of animal models and intervention of traditional Chinese medicine.Animal models and experimental medicine · 2024Review
- Plasma-Activated Polydimethylsiloxane Microstructured Pattern with Collagen for Improved Myoblast Cell Guidance.International journal of molecular sciences · 2024Article
- Ovine Mesenchymal Stem Cell Chondrogenesis on a Novel 3D-Printed Hybrid Scaffold In Vitro.Bioengineering (Basel, Switzerland) · 2024Article
- A rabbit osteochondral defect (OCD) model for evaluation of tissue engineered implants on their biosafety and efficacy in osteochondral repair.Frontiers in bioengineering and biotechnology · 2024Article
- Mechanical osteoarthritis of the hip in a one medicine concept: a narrative review.BMC veterinary research · 2023Review
- Extracellular vesicles in the treatment and prevention of osteoarthritis: can horses help us translate this therapy to humans?Extracellular vesicles and circulating nucleic acids · 2023Article
- An immunomodulatory polypeptide hydrogel for osteochondral defect repair.Bioactive materials · 2023Article
- Within or Without You? A Perspective Comparing In Situ and Ex Situ Tissue Engineering Strategies for Articular Cartilage Repair.Advanced healthcare materials · 2022Article
- Ex vivo study correlating the stiffness of the ovine patellar tendon to age and weight.International biomechanics · 2022Article
- Navigating regulatory pathways for translation of biologic cartilage repair products.Science translational medicine · 2022Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cartilage repair in terms of replacement, or regeneration of damaged or diseased articular cartilage with functional tissue, is the 'holy grail' of joint surgery. A wide spectrum of strategies for cartilage repair currently exists and several of these techniques have been reported to be associated with successful clinical outcomes for appropriately selected indications. However, based on respective advantages, disadvantages, and limitations, no single strategy, or even combination of strategies, provides surgeons with viable options for attaining successful long-term outcomes in the majority of patients. As such, development of novel techniques and optimisation of current techniques need to be, and are, the focus of a great deal of research from the basic science level to clinical trials. Translational research that bridges scientific discoveries to clinical application involves the use of animal models in order to assess safety and efficacy for regulatory approval for human use. This review article provides an overview of animal models for cartilage repair. Cite this article: Bone Joint Res 2014;4:89-94.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.