ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Aberrant functional connectivity in dissociable hippocampal networks is associated with deficits in memory.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Pooled it
- Commonalities and distinctions of static and dynamic functional connectivity density between left and right temporal lobe epilepsy.Scientific reports · 2026Article
- Longitudinal hippocampal axis in large-scale cortical systems underlying development and episodic memory.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Behaviorally meaningful functional networks mediate the effect of Alzheimer's pathology on cognition.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Aberrant intra- and internetwork functional connectivity patterns of the anterior and posterior hippocampal networks in schizophrenia.CNS neuroscience & therapeutics · 2023Article
- Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex.Brain sciences · 2023Article
- Uncovering the biological basis of control energy: Structural and metabolic correlates of energy inefficiency in temporal lobe epilepsy.Science advances · 2022Article
- Data-Driven Clustering of Functional Signals Reveals Gradients in Processing Both within the Anterior Hippocampus and across Its Long Axis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cellular Substrates of Functional Network Integration and Memory in Temporal Lobe Epilepsy.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Dynamic functional connectivity in modular organization of the hippocampal network marks memory phenotypes in temporal lobe epilepsy.Human brain mapping · 2022Article
- Abnormal Functional Connectivity of Hippocampal Subdivisions in Obstructive Sleep Apnea: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in neuroscience · 2022Article
- Verbal Learning and Longitudinal Hippocampal Network Connectivity in Temporal Lobe Epilepsy Surgery.Frontiers in neurology · 2022Article
- Functional connectivity of the hippocampus and its subfields in resting-state networks.The European journal of neuroscience · 2021Article
- High-frequency Noise-induced Hearing Loss Disrupts Functional Connectivity in Non-auditory Areas with Cognitive Disturbances.Neuroscience bulletin · 2021Article
- Tracking longitudinal language network reorganisation using functional MRI connectivity fingerprints.NeuroImage. Clinical · 2021Article
- Functional parcellation of the hippocampus by semi-supervised clustering of resting state fMRI data.Scientific reports · 2020Article
- Dynamical Mechanisms of Interictal Resting-State Functional Connectivity in Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Clinical utility of structural connectomics in predicting memory in temporal lobe epilepsy.Neurology · 2020Article
- Two nights of recovery sleep restores hippocampal connectivity but not episodic memory after total sleep deprivation.Scientific reports · 2020Article
- Hubs disruption in mesial temporal lobe epilepsy. A resting-state fMRI study on a language-and-memory network.Human brain mapping · 2020Article
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6 authors at 4 institutions in 3 countries.
Funding
Abstract
In the healthy human brain, evidence for dissociable memory networks along the anterior-posterior axis of the hippocampus suggests that this structure may not function as a unitary entity. Failure to consider these functional divisions may explain diverging results among studies of memory adaptation in disease. Using task-based and resting functional MRI, we show that chronic seizures disrupting the anterior medial temporal lobe (MTL) preserve anterior and posterior hippocampal-cortical dissociations, but alter signaling between these and other key brain regions. During performance of a memory encoding task, we found reduced neural activity in human patients with unilateral temporal lobe epilepsy relative to age-matched healthy controls, but no upregulation of fMRI signal in unaffected hippocampal subregions. Instead, patients showed aberrant resting fMRI connectivity within anterior and posterior hippocampal-cortical networks, which was associated with memory decline, distinguishing memory-intact from memory-impaired patients. Our results highlight a critical role for intact hippocampo-cortical functional communication in memory and provide evidence that chronic injury-induced functional reorganization in the diseased MTL is behavioral inefficient.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.