ArticlePloS one2014
The mechanisms underlying α-amanitin resistance in Drosophila melanogaster: a microarray analysis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Phenoconversion andHepatology forum · 2025Review
- Comparison of toxic effects of 5 macrofungi against Drosophila melanogaster.Journal of insect science (Online) · 2023Article
- A distinct strain of Arsenophonus symbiont decreases insecticide resistance in its insect host.PLoS genetics · 2018Article
- α-amanitin resistance in Drosophila melanogaster: A genome-wide association approach.PloS one · 2017Article
- Article
- Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila.PLoS genetics · 2015Article
- The secret lives of Drosophila flies.eLife · 2015Review
- Long-Term Resistance of Drosophila melanogaster to the Mushroom Toxin Alpha-Amanitin.PloS one · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rapid evolution of toxin resistance in animals has important consequences for the ecology of species and our economy. Pesticide resistance in insects has been a subject of intensive study; however, very little is known about how Drosophila species became resistant to natural toxins with ecological relevance, such as α-amanitin that is produced in deadly poisonous mushrooms. Here we performed a microarray study to elucidate the genes, chromosomal loci, molecular functions, biological processes, and cellular components that contribute to the α-amanitin resistance phenotype in Drosophila melanogaster. We suggest that toxin entry blockage through the cuticle, phase I and II detoxification, sequestration in lipid particles, and proteolytic cleavage of α-amanitin contribute in concert to this quantitative trait. We speculate that the resistance to mushroom toxins in D. melanogaster and perhaps in mycophagous Drosophila species has evolved as cross-resistance to pesticides, other xenobiotic substances, or environmental stress factors.
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Registered trials
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