ArticlePloS one2014
Identification and characterization of microRNAs in normal equine tissues by Next Generation Sequencing.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Equine MicroRNAs: Performance, Reproduction, and Disease.MicroRNA (Shariqah, United Arab Emirates) · 2026Review
- Charting the equine miRNA landscape: An integrated pipeline and browser for annotating, quantifying, and visualizing expression.PLoS genetics · 2025Article
- Transcriptomic Characterization of miRNAs inGenes · 2025Article
- Integrated analysis of miRNAs-mRNAs in skeletal muscle development revealed that novel-miR-766 affects myoblast differentiation and myofiber-type formation in sheep.Frontiers in cell and developmental biology · 2025Article
- Circulating miR-146b and miR-27b are efficient biomarkers for early diagnosis of Equidae osteoarthritis.Scientific reports · 2023Article
- Article
- Investigation of MicroRNA Biomarkers in Equine Distal Interphalangeal Joint Osteoarthritis.International journal of molecular sciences · 2022Article
- Equine synovial fluid small non-coding RNA signatures in early osteoarthritis.BMC veterinary research · 2021Article
- Differences in miRNA differential expression in whole blood between horses with sarcoid regression and progression.Journal of veterinary internal medicine · 2019Article
- Downregulation of MicroRNA eca-mir-128 in Seminal Exosomes and Enhanced Expression of CXCL16 in the Stallion Reproductive Tract Are Associated with Long-Term Persistence of Equine Arteritis Virus.Journal of virology · 2018Article
- Integrated analysis of microRNA and mRNA expressions in peripheral blood leukocytes of Warmblood horses before and after exercise.Journal of veterinary science · 2018Article
- Article
- Evaluation of microRNA expression in plasma and skeletal muscle of thoroughbred racehorses in training.BMC veterinary research · 2017Article
- Identification and Expression of Equine MER-Derived miRNAs.Molecules and cells · 2017Article
- Article
- Novel equine tissue miRNAs and breed-related miRNA expressed in serum.BMC genomics · 2016Article
- RNA sequencing as a powerful tool in searching for genes influencing health and performance traits of horses.Journal of applied genetics · 2016Review
- The miRNA biogenesis in marine bivalves.PeerJ · 2016Article
- Expression of microRNAs in Horse Plasma and Their Characteristic Nucleotide Composition.PloS one · 2016Article
- Genome-wide analysis of microRNAs identifies the lipid metabolism pathway to be a defining factor in adipose tissue from different sheep.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of microRNAs (miRNAs) as a post-transcriptional gene regulator has been elucidated in a broad range of organisms including domestic animals. Characterization of miRNAs in normal tissues is an important step to investigate the functions of miRNAs in various physiological and pathological conditions. Using Illumina Next Generation Sequencing (NGS) technology, we identified a total of 292 known and 329 novel miRNAs in normal horse tissues including skeletal muscle, colon and liver. Distinct sets of miRNAs were differentially expressed in a tissue-specific manner. The miRNA genes were distributed across all the chromosomes except chromosomes 29 and 31 in the horse reference genome. In some chromosomes, multiple miRNAs were clustered and considered to be polycistronic transcript. A base composition analysis showed that equine miRNAs had a higher frequency of A+U than G+C. Furthermore, U tended to be more frequent at the 5' end of miRNA sequences. This is the first experimental study that identifies and characterizes the global miRNA expression profile in normal horse tissues. The present study enriches the horse miRNA database and provides useful information for further research dissecting biological functions of miRNAs in horse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.