ArticlePloS one2014
Premature graying as a consequence of compromised antioxidant activity in hair bulb melanocytes and their precursors.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- Pigmentary Changes Reported with Tyrosine Kinase Inhibitors: A Narrative Review of Mechanisms and Clinical Implications.Clinical drug investigation · 2026Review
- Skin Pressing: An Easy and Reliable Method to Induce Acute Hair Greying in Mice and Useful for Studying Canities.Experimental dermatology · 2025Article
- Premature hair graying: a multifaceted phenomenon.International journal of dermatology · 2025Review
- A proteoglycan-based topical treatment for hair greying:Frontiers in medicine · 2025Article
- Anti-Graying Effects of External and Internal Treatments with Luteolin on Hair in Model Mice.Antioxidants (Basel, Switzerland) · 2024Article
- Differential expression and co-expression reveal cell types relevant to genetic disorder phenotypes.Bioinformatics (Oxford, England) · 2024Article
- Review
- Putrescine Upregulates Melanogenesis Through Modulation of MITF Transcription Factor in B16F1 Mouse Melanoma Cells.Food technology and biotechnology · 2024Article
- Is There a Rationale for the Use of an Alpha-Melanocyte-Stimulating Hormone Analog to Improve Gray Hair Repigmentation?Skin appendage disorders · 2023Article
- NRF2 in the Epidermal Pigmentary System.Biomolecules · 2022Review
- Focus on the Contribution of Oxidative Stress in Skin Aging.Antioxidants (Basel, Switzerland) · 2022Review
- Hair Graying Regulators Beyond Hair Follicle.Frontiers in physiology · 2022Article
- A Novel Pro-Melanogenic Effect of Standardized Dry Olive Leaf Extract on Primary Human Melanocytes from Lightly Pigmented and Moderately Pigmented Skin.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Stress-sensing in the human greying hair follicle: Ataxia Telangiectasia Mutated (ATM) depletion in hair bulb melanocytes in canities-prone scalp.Scientific reports · 2020Article
- Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles in vitro.PloS one · 2019Article
- Degraded melanocores are incompetent to protect epidermal keratinocytes against UV damage.Cell cycle (Georgetown, Tex.) · 2018Article
- Deoxyarbutin Possesses a Potent Skin-Lightening Capacity with No Discernible Cytotoxicity against Melanosomes.PloS one · 2016Article
- The melanocyte lineage in development and disease.Development (Cambridge, England) · 2015Review
- Assessment of Oxidative Stress in Patients with Premature Canities.International journal of trichologyArticle
- Evaluation of Systemic Oxidative Stress in Patients with Premature Canities and Correlation of Severity of Hair Graying with the Degree of Redox Imbalance.International journal of trichologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intricate coordinated mechanisms that govern the synchrony of hair growth and melanin synthesis remain largely unclear. These two events can be uncoupled in prematurely gray hair, probably due to oxidative insults that lead to the death of oxidative stress-sensitive melanocytes. In this study, we examined the gene expression profiles of middle (bulge) and lower (hair bulb) segments that had been micro-dissected from unpigmented and from normally pigmented hair follicles from the same donors using quantitative real-time RT-PCR (qPCR) arrays. We found a significant down-regulation of melanogenesis-related genes (TYR, TYRP1, MITF, PAX3, POMC) in unpigmented hair bulbs and of marker genes typical for melanocyte precursor cells (PAX3, SOX10, DCT) in unpigmented mid-segments compared with their pigmented analogues. qPCR, western blotting and spin trapping assays revealed that catalase protein expression and hydroxyl radical scavenging activities are strongly repressed in unpigmented hair follicles. These data provide the first clear evidence that compromised antioxidant activity in gray hair follicles simultaneously affects mature hair bulb melanocytes and their immature precursor cells in the bulge region.
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Registered trials
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