ArticlePloS one2014
Androgens involvement in the pathogenesis of renal stones formation.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Neutrophil to lymphocyte ratio in urolithiasis: a systematic review.BMC urology · 2025Pooled it
- Prevalence and clinical patterns of urolithiasis in sub-saharan Africa: a systematic review and meta-analysis of observational studies.BMC nephrology · 2024Pooled it
- Univariable and multivariable mendelian randomization study revealed the modifiable risk factors of urolithiasis.PloS one · 2023Pooled it
- Animal models for calcium oxalate kidney stone research.Zoological research · 2026Review
- The Effect of Boron Supplementation on Kidney Stones in Patients With Nephrolithiasis: A Double-Blind Randomized Controlled Trial.Food science & nutrition · 2025Article
- Low serum testosterone is associated with an increased risk of first-time renal calculi in men without testosterone replacement therapy.International journal of impotence research · 2025Article
- Older age and low testosterone levels are independently associated with kidney stone prevalence in men: results from a large cross-sectional study.International journal of impotence research · 2025Article
- Trend analysis of pediatric urolithiasis prevalence from 1990 to 2021 in the BRICS.Frontiers in pediatrics · 2025Article
- Bone mineral density and sex hormone binding globulin as potential mediators of the causal effect of urolithiasis on osteoporosis risk: a Mendelian randomization.Frontiers in endocrinology · 2025Article
- Trends in the burden of urolithiasis in China: an analysis from the global burden of disease study 2021.Frontiers in surgery · 2025Article
- The Hidden Link between Polycystic Ovary Syndrome and Kidney Stones: Finding from the Tehran Lipid and Glucose Study (TLGS).Diagnostics (Basel, Switzerland) · 2023Article
- Hormonal and molecular characterization of calcium oxalate stone formers predicting occurrence and recurrence.Urolithiasis · 2023Article
- In focus: perplexing increase of urinary stone disease in children, adolescent and young adult women and its economic impact.Frontiers in medicine · 2023Article
- Hypogonadism and urologic surgeries: a narrative review.Translational andrology and urology · 2022Review
- Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions.Life (Basel, Switzerland) · 2022Review
- Relationship Between Serum Testosterone Levels and Kidney Stones Prevalence in Men.Frontiers in endocrinology · 2022Article
- Metabolomics analysis of the serum from children with urolithiasis using UPLC-MS.Clinical and translational science · 2021Observational
- Association between sex hormones and kidney stones: analysis of the National Health and Nutrition Examination Survey.World journal of urology · 2021Article
- Oxalobacter formigenes reduce the risk of kidney stones in patients exposed to oral antibiotics: a case-control study.International urology and nephrology · 2021Article
- Decreased Risk of Renal Calculi in Patients Receiving Androgen Deprivation Therapy for Prostate Cancer.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe potential role for the gonadal steroids in the pathogenesis of urolithiasis, higher mean of plasma oxalate concentration and kidney calcium oxalate deposition influenced by androgens in men has been proposed. In this study, the serum levels of steroid hormones as a pathogenesis of this condition in male patients with active renal stone disease compared with controls was investigated.
methodsForty patients diagnosed with renal stones and hospitalized for further clinical treatments or referred to our office after ultrasonographic evaluations participated in the study. Forty six healthy subjects served as controls. Steroid sex hormones in the plasma samples including testosterone, free testosterone, dihydrotestosterone, estradiol, and sex hormone binding globulin were analyzed.
resultsA significant difference was observed between patients and the control subjects regarding serum testosterone, free testosterone, dihydrotestosterone, estradiol, and sex hormone binding globulin.
conclusionsBased on the results, a higher androgens level was diagnosed in renal stone patients, indicating a possibility of a substantial pathogenic role of testosterone, free testosterone, and dihydrotestosterone involvement in the pathogenesis of renal stones formation. Therefore, data presentation and further investigation on the relation between male steroids and urolithiasis is of importance and should be considered in evaluation of the etiology of the disease.
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