ArticleNature2014
Transcriptional landscape of the prenatal human brain.
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Article in Nature, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 827 papers, 3 of them syntheses that pooled it.
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827citing papers in PubMed, 3 pooled it
45.1field-weighted citation impact, top 1% of its field
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Who cites it
827 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,396 citations in OpenAlex.
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- The Genetic Architecture of the Human Corpus Callosum and its Subregions.Nature communications · 2025Pooled it
- Dissecting Schizophrenia Biology Using Pleiotropy With Cognitive Genomics.Biological psychiatry · 2025Pooled it
- Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency.Nature genetics · 2026Article
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- CCNB1IP1 regulatory evolution underlies gradual increases in cortical size and folding in primates.Nature genetics · 2026Article
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- Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants.Nature neuroscience · 2026Article
- Spatial transcriptomics reveal developmental dynamics of the human cerebral cortex and striatum.Science China. Life sciences · 2026Article
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- Systematic CRISPRi perturbation of 1,408 autism risk genes maps multilevel transcriptional convergence in human cortical neurons.bioRxiv : the preprint server for biology · 2026Article
- Hedgehog signaling activation rescues hypoxia-induced ferroptosis in human brain organoids.Neural regeneration research · 2026Article
- Solute carrier membrane transporters: emerging targets in CNS disorders.Nature reviews. Drug discovery · 2026Review
- Multiomics analysis identifies VPA-induced changes in neural progenitor cells, ventricular-like regions, and cellular microenvironment in dorsal forebrain organoids.Molecular psychiatry · 2026Article
- Convergent genetic pathways linking neuropsychiatric and ocular disorders in children.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Systematic genotype-phenotype mapping and transcriptomic analyses highlight SEMA6A as a candidate for neuronal migration defects in 5q22-q23 deletions.Journal of human genetics · 2026Article
- PPP1R21-Related neurodevelopmental disorder: Phenotypic delineation, variant spectrum, and pathophysiological mechanisms.Neurogenetics · 2026Review
- Deep learning reveals a neurocomputational mechanism predicting depression risk in adolescents.Science advances · 2026Article
- Single-cell proteomic landscape of the developing human brain.Nature biotechnology · 2026Article
- From brain networks to peripheral signatures: candidate biomarkers for major depressive disorder.Translational psychiatry · 2026Article
767 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
80 authors at 9 institutions in 1 country.
Jeremy A Miller1] Allen Institute for Brain Science, Seattle, Washington 98103, USA [2].
Song-Lin Ding1] Allen Institute for Brain Science, Seattle, Washington 98103, USA [2].
Susan M SunkinAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Kimberly A SmithAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Lydia NgAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Aaron SzaferAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Amanda EbbertAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Zackery L RileyAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Joshua J RoyallAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Kaylynn AionaAllen Institute for Brain Science, Seattle, Washington 98103, USA.
James M ArnoldAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Crissa BennetAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Darren BertagnolliAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Krissy BrounerAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Stephanie ButlerAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Shiella CaldejonAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Anita CareyAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Christine CuhaciyanAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Rachel A DalleyAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Nick DeeAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Tim A DolbeareAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Benjamin A C FacerAllen Institute for Brain Science, Seattle, Washington 98103, USA.
David FengAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Tim P FlissAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Garrett GeeAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Jeff GoldyAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Lindsey GourleyAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Benjamin W GregorAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Guangyu GuAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Robert E HowardAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Jayson M JochimAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Chihchau L KuanAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Christopher LauAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Chang-Kyu LeeAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Felix LeeAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Tracy A LemonAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Phil LesnarAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Bergen McMurrayAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Naveed MastanAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Nerick MosquedaAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Theresa Naluai-CecchiniDivision of Genetic Medicine, Department of Pediatrics, University of Washington, 1959 North East Pacific Street, Box 356320, Seattle, Washington 98195, USA.
Nhan-Kiet NgoAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Julie NyhusAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Aaron OldreAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Eric OlsonAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Jody ParenteAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Patrick D ParkerAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Sheana E ParryAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Allison Stevens1] Department of Radiology, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA [2] Computer Science and AI Lab, MIT, Cambridge, Massachusetts 02139, USA.
Mihovil PletikosDepartment of Neurobiology and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, Connecticut 06510, USA.
Melissa RedingAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Kate RollAllen Institute for Brain Science, Seattle, Washington 98103, USA.
David SandmanAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Melaine SarrealAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Sheila ShapouriAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Nadiya V ShapovalovaAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Elaine H ShenAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Nathan SjoquistAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Clifford R SlaughterbeckAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Michael SmithAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Andy J SodtAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Derric WilliamsAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Lilla ZölleiDepartment of Radiology, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
Bruce Fischl1] Department of Radiology, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA [2] Computer Science and AI Lab, MIT, Cambridge, Massachusetts 02139, USA.
Mark B Gerstein1] Program in Computational Biology and Bioinformatics, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA [2] Department of Computer Science, Yale University, New Haven, Connecticut 06520, USA.
Daniel H GeschwindProgram in Neurogenetics, Department of Neurology and Semel Institute David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA.
Ian A GlassDivision of Genetic Medicine, Department of Pediatrics, University of Washington, 1959 North East Pacific Street, Box 356320, Seattle, Washington 98195, USA.
Michael J HawrylyczAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Robert F Hevner1] Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington 98101, USA [2] Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98105, USA.
Hao HuangAdvanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
Allan R JonesAllen Institute for Brain Science, Seattle, Washington 98103, USA.
James A KnowlesZilkha Neurogenetic Institute, and Department of Psychiatry, University of Southern California, Los Angeles, California 90033, USA.
Pat Levitt1] Department of Pediatrics, Children's Hospital, Los Angeles, California 90027, USA [2] Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
John W PhillipsAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Nenad SestanDepartment of Neurobiology and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, Connecticut 06510, USA.
Paul WohnoutkaAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Chinh DangAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Amy BernardAllen Institute for Brain Science, Seattle, Washington 98103, USA.
John G HohmannAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Ed S LeinAllen Institute for Brain Science, Seattle, Washington 98103, USA.
Allen Institute for Brain Science · USAllen Institute · USUniversity of Washington · USYale University · USMassachusetts General Hospital · USChildren's Hospital of Los Angeles · USHarvard University · USThe University of Texas Southwestern Medical Center · USUniversity of Southern California · US
Funding
LABORATORY OF DEVELOPMENTAL BIOLOGYR24HD000836 · NICHD · UNIVERSITY OF WASHINGTON · PI Ian Amos Glass · 1995 to 2026
$16.9MTranscriptional Atlas of Human Brain DevelopmentRC2MH089921 · NIMH · ALLEN INSTITUTE · PI FISCHL, BRUCE, GESCHWIND, DANIEL H · 2009 to 2010
$16.2MIdentification and Characterization of Asymmetrically-Expressed GenesR37MH060233 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2006 to 2014
$5.3MStructural Development of Human Fetal BrainR01MH092535 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI HUANG, HAO · 2011 to 2020
$4.6MPineal Regulation: Control of arylalkylamine N-acetyltransferaseZ01HD008836 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI KLEIN, DAVID · 2007 to 2008
$2.0MAge-Dependent Analysis Techniques for Pediatric Structural and Diffusion MRI DataR00HD061485 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI ZOLLEI, LILLA · 2012 to 2014
$706kIntramural NIH HHS Z01 HD008836NICHD NIH HHS 5R24HD0008836NICHD NIH HHS R00 HD061485NICHD NIH HHS R24 HD000836NIMH NIH HHS R01 MH092535NIMH NIH HHS R37 MH060233NIMH NIH HHS RC2 MH089921NIMH NIH HHS RC2MH089921
Abstract
The anatomical and functional architecture of the human brain is mainly determined by prenatal transcriptional processes. We describe an anatomically comprehensive atlas of the mid-gestational human brain, including de novo reference atlases, in situ hybridization, ultra-high-resolution magnetic resonance imaging (MRI) and microarray analysis on highly discrete laser-microdissected brain regions. In developing cerebral cortex, transcriptional differences are found between different proliferative and post-mitotic layers, wherein laminar signatures reflect cellular composition and developmental processes. Cytoarchitectural differences between human and mouse have molecular correlates, including species differences in gene expression in subplate, although surprisingly we find minimal differences between the inner and outer subventricular zones even though the outer zone is expanded in humans. Both germinal and post-mitotic cortical layers exhibit fronto-temporal gradients, with particular enrichment in the frontal lobe. Finally, many neurodevelopmental disorder and human-evolution-related genes show patterned expression, potentially underlying unique features of human cortical formation. These data provide a rich, freely-accessible resource for understanding human brain development.
Indexed as
TranscriptomeAnatomy, ArtisticAnimalsAtlases as TopicBrainConserved SequenceFetusGene Expression Regulation, DevelopmentalGene Regulatory NetworksHumansMiceNeocortexSpecies Specificity
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