Evidence map›Paper›PMID 24695169›Full record

ArticleJournal of the Optical Society of America. A, Optics, image science, and vision2014

Specialized synaptic pathway for chromatic signals beneath S-cone photoreceptors is common to human, Old and New World primates.

Christian Puller, Michael B Manookin, Maureen Neitz, Jay Neitz

Open access · greenAbstract read
In one paragraph

Article in Journal of the Optical Society of America. A, Optics, image science, and vision, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. The role of syntaxins in retinal function and health.Frontiers in cellular neuroscience · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Curing color blindness--mice and nonhuman primates.Cold Spring Harbor perspectives in medicine · 2014
    Review
  8. Cone-isolating ON-OFF electroretinogram for studying chromatic pathways in the retina.Journal of the Optical Society of America. A, Optics, image science, and vision · 2014
    Article
  9. Neurobiological hypothesis of color appearance and hue perception.Journal of the Optical Society of America. A, Optics, image science, and vision · 2014
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christian Puller
Michael B Manookin
Maureen Neitz
Jay Neitz
University of Washington · US

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
YILMA SIV VACCINIA VACCINE TRIALP51RR000166 · NCRR · UNIVERSITY OF WASHINGTON · PI BAILLIE, THOMAS ALLAN · 1985 to 2011
$161.1M
Vision Research CoreP30EY001730 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 1985 to 2026
$23.5M
GENES AND VISUAL PIGMENTS OF RED/GREEN COLOR VISIONR01EY009303 · NEI · UNIVERSITY OF WASHINGTON · PI NEITZ, MAUREEN E · 1991 to 2013
$5.2M
BIOPHYSICAL MECHANISMS OF SINGLE PHOTON DETECTIONR01EY011850 · NEI · UNIVERSITY OF WASHINGTON · PI RIEKE, FREDERICK M · 1997 to 2015
$3.5M
NCRR NIH HHS P51 RR000166NEI NIH HHS P30 EY001730NEI NIH HHS P30EY001970NEI NIH HHS R01 EY009303NEI NIH HHS R01 EY011850NEI NIH HHS R01EY01730NEI NIH HHS R01EY09303NEI NIH HHS R01EY11850NIH HHS P51 OD010425
6 · The paper itself

Abstract

The distribution of the soluble NSF-attachment protein receptor protein syntaxin-4 and the Na-K-Cl cotransporter (NKCC) were investigated in the outer plexiform layer of human retina using immunohistochemistry. Both proteins, which are proposed to be components of a gamma-aminobutyric acid mediated feed-forward circuit from horizontal cells directly to bipolar cells, were enriched beneath S-cones. The expression pattern of syntaxin-4 was further analyzed in baboon and marmoset to determine if the synaptic specialization is common to primates. Syntaxin-4 was enriched beneath S-cones in both species, which together with the human results indicates that this specialization may have evolved for the purpose of mediating unique color vision capacities that are exclusive to primates.

Indexed as

Signal TransductionAgedAnimalsCallithrixColor PerceptionColor VisionEvolution, MolecularFemaleGene Expression RegulationHumansPapioQa-SNARE ProteinsRetinal Cone Photoreceptor CellsSpecies SpecificitySynapsesQa-SNARE Proteinssyntaxin 4, human

Identifiers

PMID24695169
PMCPMC4282935
OpenAlexW1972145716

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.