ArticlePloS one2014
Evidence of positive selection in mitochondrial complexes I and V of the African elephant.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Rapid evolution of genes with anti-cancer functions during the origins of large bodies and cancer resistance in elephants.bioRxiv : the preprint server for biology · 2024Article
- Population genetic structure and historical demography of the population of forest elephants in Côte d'Ivoire.PloS one · 2024Article
- Barriers to chimpanzee gene flow at the south-east edge of their distribution.Molecular ecology · 2023Article
- Mitogenome selection in the evolution of key ecological strategies in the ancient hexapod class Collembola.Scientific reports · 2022Article
- Positive selection over the mitochondrial genome and its role in the diversification of gentoo penguins in response to adaptation in isolation.Scientific reports · 2022Article
- Comparative mitogenomic analyses provide evolutionary insights into the retrolateral tibial apophysis clade (Araneae: Entelegynae).Frontiers in genetics · 2022Article
- Lifespan Extension in Long-Lived Vertebrates Rooted in Ecological Adaptation.Frontiers in cell and developmental biology · 2021Review
- The role of selection in the evolution of marine turtles mitogenomes.Scientific reports · 2020Article
- Article
- Signals of positive selection in mitochondrial protein-coding genes of woolly mammoth: Adaptation to extreme environments?Ecology and evolution · 2019Article
- Assessing the fitness consequences of mitonuclear interactions in natural populations.Biological reviews of the Cambridge Philosophical Society · 2019Article
- Article
- Analysis of the coding sequences of clownfish reveals molecular convergence in the evolution of lifespan.BMC evolutionary biology · 2019Article
- Evolutionary analysis of mitochondrially encoded proteins of toad-headed lizards, Phrynocephalus, along an altitudinal gradient.BMC genomics · 2018Article
- Testing for the Occurrence of Selective Episodes During the Divergence of Otophysan Fishes: Insights from Mitogenomics.Journal of molecular evolution · 2017Article
- Integrative Approaches for Studying Mitochondrial and Nuclear Genome Co-evolution in Oxidative Phosphorylation.Frontiers in genetics · 2017Article
- Genome sequence, population history, and pelage genetics of the endangered African wild dog (Lycaon pictus).BMC genomics · 2016Article
- Conservative and compensatory evolution in oxidative phosphorylation complexes of angiosperms with highly divergent rates of mitochondrial genome evolution.Evolution; international journal of organic evolution · 2015Article
- Initial Evidence for Adaptive Selection on the NADH Subunit Two of Freshwater Dolphins by Analyses of Mitochondrial Genomes.PloS one · 2015Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As species evolve, they become adapted to their local environments. Detecting the genetic signature of selection and connecting that to the phenotype of the organism, however, is challenging. Here we report using an integrative approach that combines DNA sequencing with structural biology analyses to assess the effect of selection on residues in the mitochondrial DNA of the two species of African elephants. We detected evidence of positive selection acting on residues in complexes I and V, and we used homology protein structure modeling to assess the effect of the biochemical properties of the selected residues on the enzyme structure. Given the role these enzymes play in oxidative phosphorylation, we propose that the selected residues may contribute to the metabolic adaptation of forest and savanna elephants to their unique habitats.
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