Evidence map›Paper›PMID 24694924›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014

An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits.

Dirk Scheele, Keith M Kendrick, Christoph Khouri, Elisa Kretzer, Thomas E Schläpfer, Birgit Stoffel-Wagner, Onur Güntürkün, Wolfgang Maier, René Hurlemann

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 2 pooled it
26.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 2 syntheses or guidelines pooled it, 175 citations in OpenAlex.

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  8. Common and dissociable effects of oxytocin and lorazepam on the neurocircuitry of fear.Proceedings of the National Academy of Sciences of the United States of America · 2020
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  9. Effects of MDMA on attention to positive social cues and pleasantness of affective touch.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
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  20. Oxytocin Facilitates Pavlovian Fear Learning in Males.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Dirk Scheele1] Department of Psychiatry, University of Bonn, Bonn, Germany [2] Division of Medical Psychology, University of Bonn, Bonn, Germany.
Keith M KendrickKey Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China (UESTC), Chengdu, PR China.
Christoph Khouri1] Department of Psychiatry, University of Bonn, Bonn, Germany [2] Division of Medical Psychology, University of Bonn, Bonn, Germany.
Elisa Kretzer1] Department of Psychiatry, University of Bonn, Bonn, Germany [2] Division of Medical Psychology, University of Bonn, Bonn, Germany.
Thomas E Schläpfer1] Department of Psychiatry, University of Bonn, Bonn, Germany [2] Departments of Psychiatry and Mental Health, Johns Hopkins University, Baltimore, MD, USA.
Birgit Stoffel-WagnerDepartment of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany.
Onur GüntürkünDepartment of Biopsychology, Ruhr University, Bochum, Germany.
Wolfgang Maier1] Department of Psychiatry, University of Bonn, Bonn, Germany [2] German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
René Hurlemann1] Department of Psychiatry, University of Bonn, Bonn, Germany [2] Division of Medical Psychology, University of Bonn, Bonn, Germany.
University of Bonn · DERuhr University Bochum · DEUniversity of Electronic Science and Technology of China · CN

Funding

Synaptic regulation of affective behaviorsR01MH096899 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NINAN, IPE · 2012 to 2013
$496k
6 · The paper itself

Abstract

Social communication through touch and mutual grooming can convey highly salient socio-emotional signals and has been shown to involve the neuropeptide oxytocin (OXT) in several species. Less is known about the modulatory influence of OXT on the neural and emotional responses to human interpersonal touch. The present randomized placebo (PLC)-controlled within-subject pharmaco-functional magnetic resonance imaging (fMRI) study was designed to test the hypothesis that a single intranasal dose of synthetic OXT (24 IU) would facilitate both neural and emotional responses to interpersonal touch in a context- (female vs male touch) and trait- (autistic trait load) specific manner. Specifically, the experimental rationale was to manipulate the reward value of interpersonal touch independent of the intensity and type of actual cutaneous stimulation administered. Thus, 40 heterosexual males believed that they were touched by either a man or a woman, although in fact an identical pattern of touch was always given by the same female experimenter blind to condition type. Our results show that OXT increased the perceived pleasantness of female, but not male touch, and associated neural responses in insula, precuneus, orbitofrontal, and pregenual anterior cingulate cortex. Moreover, the behavioral and neural effects of OXT were negatively correlated with autistic-like traits. Taken together, this is the first study to show that the perceived hedonic value of human heterosexual interpersonal touch is facilitated by OXT in men, but that its behavioral and neural effects in this context are blunted in individuals with autistic traits.

Indexed as

Administration, IntranasalAdultAutistic DisorderBrainBrain MappingCentral Nervous System AgentsDouble-Blind MethodEmotionsHeterosexualityHumansInterpersonal RelationsMagnetic Resonance ImagingMaleOxytocinRewardTouch PerceptionCentral Nervous System AgentsOxytocin

Identifiers

PMID24694924
PMCPMC4104346
OpenAlexW2138834433

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.