Evidence map›Paper›PMID 24694747›Full record

ArticlePloS one2014

The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010.

Alize J Ferrari, Rosana E Norman, Greg Freedman, Amanda J Baxter, Jane E Pirkis, Meredith G Harris, Andrew Page, Emily Carnahan, Louisa Degenhardt, Theo Vos and 1 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02843997 (Endophenotype Characterization of a Family Psychiatric Disorder of the Bipolar Spectrum, With an Autosomal Dominant Expression), which is not on this map. Cited by 188 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
188citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02843997 naunknown statusnot on this mapstarted 2015, after this paper: background citation

Endophenotype Characterization of a Family Psychiatric Disorder of the Bipolar Spectrum, With an Autosomal Dominant Expression

TypeinterventionalSponsorUniversity Hospital, GrenobleRan2015 to 2018Enrolled29ConditionsHealthy VolunteerArmsEndophenotype and sequencing
3 · Its place in the literature

Who cites it

188 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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  12. Psychosocial interventions for self-harm in adults.The Cochrane database of systematic reviews · 2021
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  13. Pharmacological interventions for self-harm in adults.The Cochrane database of systematic reviews · 2021
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128 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alize J FerrariUniversity of Queensland, School of Population Health, Herston, Queensland, Australia; Queensland Centre for Mental Health Research, Wacol, Queensland, Australia.
Rosana E NormanUniversity of Queensland, School of Population Health, Herston, Queensland, Australia; Queensland Children's Medical Research Institute, University of Queensland, Herston, Queensland, Australia.
Greg FreedmanInstitute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America.
Amanda J BaxterUniversity of Queensland, School of Population Health, Herston, Queensland, Australia; Queensland Centre for Mental Health Research, Wacol, Queensland, Australia.
Jane E PirkisMelbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
Meredith G HarrisUniversity of Queensland, School of Population Health, Herston, Queensland, Australia; Queensland Centre for Mental Health Research, Wacol, Queensland, Australia.
Andrew PageSchool of Science and Health, University of Western Sydney, Campbelltown, New South Wales, Australia.
Emily CarnahanInstitute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America.
Louisa DegenhardtMelbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia; National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia.
Theo VosUniversity of Queensland, School of Population Health, Herston, Queensland, Australia; Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America.
Harvey A WhitefordUniversity of Queensland, School of Population Health, Herston, Queensland, Australia; Queensland Centre for Mental Health Research, Wacol, Queensland, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Global Burden of Disease Study 2010 (GBD 2010) identified mental and substance use disorders as the 5th leading contributor of burden in 2010, measured by disability adjusted life years (DALYs). This estimate was incomplete as it excluded burden resulting from the increased risk of suicide captured elsewhere in GBD 2010's mutually exclusive list of diseases and injuries. Here, we estimate suicide DALYs attributable to mental and substance use disorders.

methodsRelative-risk estimates of suicide due to mental and substance use disorders and the global prevalence of each disorder were used to estimate population attributable fractions. These were adjusted for global differences in the proportion of suicide due to mental and substance use disorders compared to other causes then multiplied by suicide DALYs reported in GBD 2010 to estimate attributable DALYs (with 95% uncertainty).

resultsMental and substance use disorders were responsible for 22.5 million (14.8-29.8 million) of the 36.2 million (26.5-44.3 million) DALYs allocated to suicide in 2010. Depression was responsible for the largest proportion of suicide DALYs (46.1% (28.0%-60.8%)) and anorexia nervosa the lowest (0.2% (0.02%-0.5%)). DALYs occurred throughout the lifespan, with the largest proportion found in Eastern Europe and Asia, and males aged 20-30 years. The inclusion of attributable suicide DALYs would have increased the overall burden of mental and substance use disorders (assigned to them in GBD 2010 as a direct cause) from 7.4% (6.2%-8.6%) to 8.3% (7.1%-9.6%) of global DALYs, and would have changed the global ranking from 5th to 3rd leading cause of burden.

conclusionsCapturing the suicide burden attributable to mental and substance use disorders allows for more accurate estimates of burden. More consideration needs to be given to interventions targeted to populations with, or at risk for, mental and substance use disorders as an effective strategy for suicide prevention.

Indexed as

Cost of IllnessSuicide PreventionFemaleHumansMaleMental DisordersSubstance-Related Disorders

Identifiers

PMID24694747
PMCPMC3973668

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.