Trial reportPloS one2014
The relevance of short-range fibers to cognitive efficiency and brain activation in aging and dementia.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Task-based fMRI brain activation in mild cognitive impairment and Alzheimer's disease: an ALE meta-analysis.GeroScience · 2026Pooled it
- Brain Structure-Function Association as a Compensatory Factor in Cognitive Aging.bioRxiv : the preprint server for biology · 2026Article
- Assessment of the Depiction of Superficial White Matter Using Ultra-High-Resolution Diffusion MRI.Human brain mapping · 2024Article
- Long-range white matter fibres and post-stroke verbal and non-verbal cognition.Brain communications · 2024Article
- The effect of loss incentives on prospective memory in healthy older adults: study protocol of a randomized controlled trial using ultra-high field fMRI.BMC psychiatry · 2023Article
- Diabetes, brain health, and treatment gains in post-stroke aphasia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Superficial white matter across development, young adulthood, and aging: volume, thickness, and relationship with cortical features.Brain structure & function · 2023Article
- Detecting microstructural alterations of cerebral white matter associated with breast cancer and chemotherapy revealed by generalized q-sampling MRI.Frontiers in psychiatry · 2023Article
- The effect of EEG and fNIRS in the digital assessment and digital therapy of Alzheimer's disease: a systematic review.Frontiers in neuroscience · 2023Review
- Inhibitory dysfunction may cause prospective memory impairment in temporal lobe epilepsy (TLE) patients: an event-related potential study.Frontiers in human neuroscience · 2023Article
- Cortical Short-Range Fiber Connectivity and Its Association With Deep Brain White Matter Hyperintensities in Older Diabetic People With Low Serum Vitamin BFrontiers in aging neuroscience · 2022Article
- Differential Patterns of Gyral and Sulcal Morphological Changes During Normal Aging Process.Frontiers in aging neuroscience · 2021Article
- Loss and dispersion of superficial white matter in Alzheimer's disease: a diffusion MRI study.Brain communications · 2021Article
- Gray matter T1-w/T2-w ratios are higher in Alzheimer's disease.Human brain mapping · 2019Article
- Analysis of correlation between cerebral perfusion and KIM score of white matter lesions in patients with Alzheimer's disease.Neuropsychiatric disease and treatment · 2019Article
- The Relation Between White Matter Microstructure and Network Complexity: Implications for Processing Efficiency.Frontiers in integrative neuroscience · 2018Article
- Scale-integrated Network Hubs of the White Matter Structural Network.Scientific reports · 2017Article
- Early development of structural networks and the impact of prematurity on brain connectivity.NeuroImage · 2017Article
- Quantifying indices of short- and long-range white matter connectivity at each cortical vertex.PloS one · 2017Article
- The superficial white matter in Alzheimer's disease.Human brain mapping · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integrity of structural connectivity in a functional brain network supports the efficiency of neural processing within relevant brain regions. This study aimed to quantitatively investigate the short- and long-range fibers, and their differential roles in the lower cognitive efficiency in aging and dementia. Three groups of healthy young, healthy older adults and patients with Alzheimer's disease (AD) participated in this combined functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) study on prospective memory (PM). Short- and long-range fiber tracts within the PM task engaged brain networks were generated. The correlation between the fMRI signal change, PM performance and the DTI characters were calculated. FMRI results showed that the PM-specific frontal activations in three groups were distributed hierarchically along the rostrocaudal axis in the frontal lobe. In an overall PM condition generally activated brain network among the three groups, tractography was used to generate the short-range fibers, and they were found impaired in both healthy older adults and AD patients. However, the long-range fiber tracts were only impaired in AD. Additionally, the mean diffusivity (MD) of short-range but not long-range fibers was positively correlated with fMRI signal change and negatively correlated with the efficiency of PM performance. This study suggests that the disintegrity of short-range fibers may contribute more to the lower cognitive efficiency and higher compensatory brain activation in healthy older adults and more in AD patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.