ArticleInternational journal of obesity (2005)2014
Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes.
Article in International journal of obesity (2005), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Predictors of Transitions From GADA as the Initial Autoantibody to Multiple Autoantibodies of Type 1 Diabetes in Children at Risk by a Dynamic Prediction Model.Pediatric diabetes · 2025Article
- Severe Liver Damage in an Obese Patient: Onset of Celiac Disease or Overlap Syndrome?Diagnostics (Basel, Switzerland) · 2024Article
- Physical activity and progression to type 1 diabetes in children and youth with islet autoimmunity: The diabetes autoimmunity study in the young.Pediatric diabetes · 2022Article
- Breastfeeding on childhood obesity in children were large-for-gestational age: retrospective study from birth to 4 years.Scientific reports · 2022Article
- Growth in Children with HLA-Conferred Susceptibility to Type 1 Diabetes.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Relationship between Obstetric Mode of Delivery and Risk of Overweight/Obesity in 1- to 4-Year-Old Children.Obesity facts · 2022Article
- The Multifactorial Progression from the Islet Autoimmunity to Type 1 Diabetes in Children.International journal of molecular sciences · 2021Review
- Sex-specific associations between prenatal antibiotics exposure and offspring's body mass index.International journal of obesity (2005) · 2020Article
- Cross-Country Comparisons of Physical Activity and Sedentary Behavior among 5-Year-Old Children.International journal of pediatrics · 2020Article
- Article
- Interaction Between Overweight and Genotypes of HLA, TCF7L2, and FTO in Relation to the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2019Article
- Differential genome-wide DNA methylation patterns in childhood obesity.BMC research notes · 2019Article
- Associations of Maternal Diabetes During Pregnancy with Overweight in Offspring: Results from the Prospective TEDDY Study.Obesity (Silver Spring, Md.) · 2018Article
- Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes.International journal of epidemiology · 2018Article
- Intake of Energy and Protein is Associated with Overweight Risk at Age 5.5 Years: Results from the Prospective TEDDY Study.Obesity (Silver Spring, Md.) · 2017Article
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16 authors.
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Abstract
objectivesBody size is postulated to modulate type 1 diabetes as either a trigger of islet autoimmunity or an accelerator to clinical onset after seroconversion. As overweight and obesity continue to rise among children, the aim of this study was to determine whether human leukocyte antigen DQ (HLA-DQ) genotypes may be related to body size among children genetically at risk for type 1 diabetes.
methodsRepeated measures of weight and height were collected from 5969 children 2-4 years of age enrolled in The Environmental Determinants of Diabetes in the Young prospective study. Overweight and obesity was determined by the International Obesity Task Force cutoff values that correspond to body mass index (BMI) of 25 and 30 kg m(-)(2) at age 18.
resultsThe average BMI was comparable across specific HLA genotypes at every age point. The proportion of overweight was not different by HL A, but percent obesity varied by age with a decreasing trend among DQ2/8 carriers (P for trend=0.0315). A multivariable regression model suggested DQ2/2 was associated with higher obesity risk at age 4 (odds ratio, 2.41; 95% confidence interval, 1.21-4.80) after adjusting for the development of islet autoantibody and/or type 1 diabetes.
conclusionsThe HLA-DQ2/2 genotype may predispose to obesity among 2-4-year-old children with genetic risk for type 1 diabetes.
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