ArticleBMC gastroenterology2014
Celiac disease risk varies between birth cohorts, generating hypotheses about causality: evidence from 36 years of population-based follow-up.
Article in BMC gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- Is the clinical pattern of pediatric celiac disease changing? A thirty-years real-life experience of an Italian center.Italian journal of pediatrics · 2021Observational
- Efficient implementation of the 'non-biopsy approach' for the diagnosis of childhood celiac disease in the Netherlands: a national prospective evaluation 2010-2013.European journal of pediatrics · 2021Article
- Is mass screening for coeliac disease a wise use of resources? A health economic evaluation.BMC gastroenterology · 2021Article
- Chronic Inflammatory Diseases - Diabetes Mellitus, Rheumatoid Arthritis, Coeliac Disease, Crohn's Disease, and Ulcerative Colitis Among the Offspring of Affected Parents: A Danish Population-Based Registry Study.Clinical epidemiology · 2021Article
- Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973-2016.Clinical epidemiology · 2020Article
- Effect of childhood coeliac disease on ninth grade school performance: evidence from a population-based study.Archives of disease in childhood · 2018Article
- Old Fashioned vs. Ultra-Processed-Based Current Diets: Possible Implication in the Increased Susceptibility to Type 1 Diabetes and Celiac Disease in Childhood.Foods (Basel, Switzerland) · 2017Review
- Article
- Season and region of birth as risk factors for coeliac disease a key to the aetiology?Archives of disease in childhood · 2016Article
- Breastfeeding and Complementary Feeding.Deutsches Arzteblatt international · 2016Review
- Maternal and perinatal conditions and the risk of developing celiac disease during childhood.BMC pediatrics · 2016Article
- Celiac disease: a disorder emerging from antiquity, its evolving classification and risk, and potential new treatment paradigms.Gut and liver · 2015Review
- Unusually High Incidence of Paediatric Coeliac Disease in Sweden during the Period 1973 - 2013.PloS one · 2015Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCeliac disease (CD) is a major public health problem with estimated 1-3% prevalence in the general population. In recent years an increase in CD prevalence has been reported both in Sweden and worldwide. This study aimed at examining the annual incidence rate of biopsy-proven celiac disease among children in Sweden over a 36-year period, to assess variations by age, sex and birth cohort, and to assess the clinical impact of these changes.
methodsThe National Swedish Childhood CD Register was used to identify 9107 children aged 0-14.9 years who were diagnosed with CD during the period 1973 to 2009. From 1973 to 1990 the register covered 15% of the nation, this increased to 40% during 1991-1997; a full national coverage was obtained from 1998 onwards. Estimations for the annual incidence rate, cumulative incidence and clinical impact by age groups, calendar month and birth cohorts were made.
resultsCD incidence is continuing to increase in the child population aged 2-14.9 years. A continued variation in CD incidence was observed in children aged 0-1.9 years, characterized by a marked decrease in most recent years. The median age at diagnosis has increased from 1.0 year in the 1970s to 6.8 years in 2009. The average number of new cases has risen from ~200 during 1973-1983 to ~600 during 2004-2009. In the birth cohorts of 2000-2002 the cumulative incidence even exceeded that of the epidemic cohorts at comparable ages. The highest cumulative incidence was observed in the birth cohorts of 1985-1995 and 2000-2002.
conclusionsCD risk varies between birth cohorts, suggesting cyclic environmental and/or lifestyle risk factors in CD etiology. More research on underlying risk factors is required in order to move forward with preventive strategies.
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