ArticleBMC psychiatry2014
Distribution of tract deficits in schizophrenia.
Article in BMC psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Effects of Adapted Physical Activity on White Matter Integrity in Patients with Schizophrenia.Brain sciences · 2024Article
- Cognitive deficits, clinical variables, and white matter microstructure in schizophrenia: a multisite harmonization study.Molecular psychiatry · 2022Article
- Elucidating the relationship between white matter structure, demographic, and clinical variables in schizophrenia-a multicenter harmonized diffusion tensor imaging study.Molecular psychiatry · 2021Article
- BDNF Serum Levels are Associated With White Matter Microstructure in Schizophrenia - A Pilot Study.Frontiers in psychiatry · 2020Article
- Structural Covariance Reveals Alterations in Control and Salience Network Integrity in Chronic Schizophrenia.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: A tract-specific analysis study.Brain and behavior · 2019Article
- Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders.Journal of autism and developmental disorders · 2019Article
- Altered frontal white matter asymmetry and its implications for cognition in schizophrenia: A tractography study.NeuroImage. Clinical · 2019Article
- Aberrant Hyperconnectivity in the Motor System at Rest Is Linked to Motor Abnormalities in Schizophrenia Spectrum Disorders.Schizophrenia bulletin · 2017Article
- Diffusion-weighted tractography in the common marmoset monkey at 9.4T.Journal of neurophysiology · 2017Article
- Vulnerability of white matter tracts and cognition to the SOD2 polymorphism: A preliminary study of antioxidant defense genes in brain aging.Behavioural brain research · 2017Article
- ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide.NeuroImage · 2017Review
- Similar white matter changes in schizophrenia and bipolar disorder: A tract-based spatial statistics study.PloS one · 2017Article
- No Association between Cortical Gyrification or Intrinsic Curvature and Attention-deficit/Hyperactivity Disorder in Adolescents and Young Adults.Frontiers in neuroscience · 2017Article
- White matter correlates of psychosis-linked traits support continuity between personality and psychopathology.Journal of abnormal psychology · 2016Article
- Tractography Analysis of 5 White Matter Bundles and Their Clinical and Cognitive Correlates in Early-Course Schizophrenia.Schizophrenia bulletin · 2016Article
- Myelination-related genes are associated with decreased white matter integrity in schizophrenia.European journal of human genetics : EJHG · 2016Article
- Schizophrenia Patients Demonstrate Both Inter-Voxel Level and Intra-Voxel Level White Matter Alterations.PloS one · 2016Article
- Altered Cerebellar White Matter Integrity in Patients with Mild Traumatic Brain Injury in the Acute Stage.PloS one · 2016Article
- MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia.Neuroscience letters · 2015Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 6 countries.
Funding
Abstract
backgroundGray and white matter brain changes have been found in schizophrenia but the anatomical organizing process underlying these changes remains unknown. We aimed to identify gray and white matter volumetric changes in a group of patients with schizophrenia and to quantify the distribution of white matter tract changes using a novel approach which applied three complementary analyses to diffusion imaging data.
methods21 patients with schizophrenia and 21 matched control subjects underwent brain magnetic resonance imaging. Gray and white matter volume differences were investigated using Voxel-based Morphometry (VBM). White matter diffusion changes were located using Tract Based Spatial Statistics (TBSS) and quantified within a standard atlas. Tracts where significant regional differences were located were examined using fiber tractography.
resultsNo significant differences in gray or white matter volumetry were found between the two groups. Using TBSS the schizophrenia group showed significantly lower fractional anisotropy (FA) compared to the controls in regions (false discovery rate <0.05) including the genu, body and splenium of the corpus callosum and the left anterior limb of the internal capsule (ALIC). Using fiber tractography, FA was significantly lower in schizophrenia in the corpus callosum genu (p = 0.003).
conclusionsIn schizophrenia, white matter diffusion deficits are prominent in medial frontal regions. These changes are consistent with the results of previous studies which have detected white matter changes in these areas. The pathology of schizophrenia may preferentially affect the prefrontal-thalamic white matter circuits traversing these regions.
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