ArticleThe New England journal of medicine2014
Thyroid hormone inactivation in gastrointestinal stromal tumors.
Article in The New England journal of medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement.Thyroid : official journal of the American Thyroid Association · 2014Guideline
- From Tradition to Future: Pathophysiological Mechanisms and Clinical Research Progress in the Treatment of Hypothyroidism with Traditional Chinese Medicine--A Narrative Review.Therapeutics and clinical risk management · 2026Review
- Article
- Unusual causes of hyperthyrotropinemia and differential diagnosis of primary hypothyroidism: a revised diagnostic flowchart.European thyroid journal · 2023Review
- Article
- Consumptive hypothyroidism in a patient with malignant rhabdoid tumor of the kidney: case report on a newly found association.European thyroid journal · 2022Article
- Hypothyroidism.Nature reviews. Disease primers · 2022Review
- Optimal Thyroid Hormone Replacement Dose in Immune Checkpoint Inhibitor-Associated Hypothyroidism Is Distinct from Hashimoto's Thyroiditis.Thyroid : official journal of the American Thyroid Association · 2022Article
- Current update on molecular cytogenetics, diagnosis and management of gastrointestinal stromal tumors.World journal of gastroenterology · 2021Review
- Gastrointestinal Stromal Tumor as a Rare Cause of Abdominal Mass: A Case Report and Literature Review.Cureus · 2021Article
- Decreased expression of the thyroid hormone-inactivating enzyme type 3 deiodinase is associated with lower survival rates in breast cancer.Scientific reports · 2020Article
- Gastrointestinal stromal tumors: A multidisciplinary challenge.World journal of gastroenterology · 2018Review
- The Deiodinase Trio and Thyroid Hormone Signaling.Methods in molecular biology (Clifton, N.J.) · 2018Review
- Consumptive Hypothyroidism: Case Report of Hepatic Hemangioendotheliomas Successfully Treated with Vincristine and Systematic Review of the Syndrome.European thyroid journal · 2017Article
- Consumptive hypothyroidism in solitary cutaneous haemangioma.BMJ case reports · 2017Article
- Combination therapeutics in complex diseases.Journal of cellular and molecular medicine · 2016Review
- Future options of anti-angiogenic cancer therapy.Chinese journal of cancer · 2016Article
- Decade in review-thyroid disease: The endocrinology of thyroid disease from 2005 to 2015.Nature reviews. Endocrinology · 2015Article
- Defending plasma T3 is a biological priority.Clinical endocrinology · 2014Review
- Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis.Endocrinology · 2014Article
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
17 authors at 7 institutions in 2 countries.
Funding
Abstract
Gastrointestinal stromal tumors (GISTs) are resistant to traditional chemotherapy but are responsive to the tyrosine kinase inhibitors imatinib and sunitinib. The use of these agents has improved the outcome for patients but is associated with adverse effects, including hypothyroidism. Multiple mechanisms of this effect have been proposed, including decreased iodine organification and glandular capillary regression. Here we report the finding of consumptive hypothyroidism caused by marked overexpression of the thyroid hormone-inactivating enzyme type 3 iodothyronine deiodinase (D3) within the tumor. Affected patients warrant increased monitoring and may require supernormal thyroid hormone supplementation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.