Evidence map›Paper›PMID 24693429›Full record

ArticleJournal of aging research2014

Association of leukocyte telomere length with fatigue in nondisabled older adults.

Laila Bendix, Mikael Thinggaard, Masayuki Kimura, Abraham Aviv, Kaare Christensen, Merete Osler, Kirsten Avlund

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of aging research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laila BendixDanish Aging Research Center, Universities of Southern Denmark, Aarhus, and Copenhagen, Denmark ; Section of Social Medicine, Department of Public Health, University of Copenhagen, P.O. Box 2099, 1014 Copenhagen K, Denmark.
Mikael ThinggaardDanish Aging Research Center, Universities of Southern Denmark, Aarhus, and Copenhagen, Denmark ; Epidemiology, Institute of Public Health, University of Southern Denmark, JB Winslowsvej 9B, 5000 Odense C, Denmark.ORCID 0000-0002-7029-453X
Masayuki KimuraThe Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA.
Abraham AvivThe Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA.
Kaare ChristensenDanish Aging Research Center, Universities of Southern Denmark, Aarhus, and Copenhagen, Denmark ; Epidemiology, Institute of Public Health, University of Southern Denmark, JB Winslowsvej 9B, 5000 Odense C, Denmark ; The Danish Twin Registry, Institute of Public Health, University of Southern Denmark, JB Winslowsvej 9B, 5000 Odense C, Denmark ; Department of Clinical Genetics and Department of Biochemistry and Pharmacology, Odense University Hospital, 5000 Odense C, Denmark ; Center for Healthy Aging, University of Copenhagen, 2200 Copenhagen N, Denmark.
Merete OslerDanish Aging Research Center, Universities of Southern Denmark, Aarhus, and Copenhagen, Denmark ; Section of Social Medicine, Department of Public Health, University of Copenhagen, P.O. Box 2099, 1014 Copenhagen K, Denmark ; Center for Healthy Aging, University of Copenhagen, 2200 Copenhagen N, Denmark ; Research Center for Prevention and Health, The Capital Region of Denmark, 2600 Glostrup, Denmark.
Kirsten AvlundDanish Aging Research Center, Universities of Southern Denmark, Aarhus, and Copenhagen, Denmark ; Section of Social Medicine, Department of Public Health, University of Copenhagen, P.O. Box 2099, 1014 Copenhagen K, Denmark ; Center for Healthy Aging, University of Copenhagen, 2200 Copenhagen N, Denmark.

Funding

TRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI YASHIN, ANATOLIY I · 1990 to 2008
$17.5M
THE RANGE OF MALE-FEMALE MORTALITY DIFFERENCESP01AG031719 · NIA · DUKE UNIVERSITY · PI CHRISTENSEN, KAARE · 2009 to 2020
$10.2M
Leukocyte TelomerE Dynamics, Gender, Menopause, Insulin Resistance and SurvivalR01AG030678 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI AVIV, ABRAHAM · 2009 to 2013
$2.2M
NIA NIH HHS P01 AG008761NIA NIH HHS R01 AG030678
6 · The paper itself

Abstract

Introduction. Fatigue is often present in older adults with no identified underlying cause. The accruing burden of oxidative stress and inflammation might be underlying factors of fatigue. We therefore hypothesized that leukocyte telomere length (LTL) is relatively short in older adults who experience fatigue. Materials and Methods. We assessed 439 older nondisabled Danish twins. LTL was measured using Southern blots of terminal restriction fragments. Fatigue was measured by the Mob-T Scale based on questions on whether the respondents felt fatigued after performing six mobility items. Results. LTL was significantly associated with fatigue (P = 0.023), showing an increase of 0.038 kb/fatigue score unit. Aging-related diseases and mental health did not explain the association, while lifestyle factors slightly attenuated the estimates. Conclusion. Our results support an association between LTL and fatigue. Further studies are required to confirm this finding and the link of LTL with oxidative stress/inflammation over the life course.

Identifiers

PMID24693429
PMCPMC3945148

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.