Evidence map›Paper›PMID 24693287›Full record

ArticleInternational journal of dentistry2014

Anthocyanin incorporated dental copolymer: bacterial growth inhibition, mechanical properties, and compound release rates and stability by (1)h NMR.

Halyna Hrynash, Vinay Kumar Pilly, Alexandra Mankovskaia, Yaoyang Xiong, Getulio Nogueira Filho, Eduardo Bresciani, Céline Marie Lévesque, Anuradha Prakki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of dentistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Halyna HrynashDepartment of Clinical Sciences-Restorative, Faculty of Dentistry, University of Toronto, 124 Edward Street, Room 352C, Toronto, ON, Canada M5G 1G6.
Vinay Kumar PillyDepartment of Biological and Diagnostic Sciences-Dental Public Health, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, ON, Canada M5G 1G6.
Alexandra MankovskaiaDepartment of Biological and Diagnostic Sciences-Oral Microbiology, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, ON, Canada M5G 1G6.
Yaoyang XiongDepartment of Prosthodontics, School of Medicine, Shanghai Jiaotong University, 639 Zhizaoju Road, Shanghai 9th Hospital, Shanghai 200011, China.
Getulio Nogueira FilhoDepartment of Biological and Diagnostic Sciences-Preventive Dentistry, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, ON, Canada M5G 1G6.
Eduardo BrescianiDepartment of Restorative Dentistry, Institute of Science and Technology, Universidade Estadual Paulista (UNESP), Avenida Eng. Francisco José Longo 777, 12245-000 São José dos Campos, SP, Brazil.
Céline Marie LévesqueDepartment of Biological and Diagnostic Sciences-Oral Microbiology, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, ON, Canada M5G 1G6.
Anuradha PrakkiDepartment of Clinical Sciences-Restorative, Faculty of Dentistry, University of Toronto, 124 Edward Street, Room 352C, Toronto, ON, Canada M5G 1G6.ORCID 0000-0002-8969-9043
University of Toronto · CAShanghai Jiao Tong University · CNUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective. To evaluate bacterial growth inhibition, mechanical properties, and compound release rate and stability of copolymers incorporated with anthocyanin (ACY; Vaccinium macrocarpon). Methods. Resin samples were prepared (Bis-GMA/TEGDMA at 70/30 mol%) and incorporated with 2 w/w% of either ACY or chlorhexidine (CHX), except for the control group. Samples were individually immersed in a bacterial culture (Streptococcus mutans) for 24 h. Cell viability (n = 3) was assessed by counting the number of colony forming units on replica agar plates. Flexural strength (FS) and elastic modulus (E) were tested on a universal testing machine (n = 8). Compound release and chemical stability were evaluated by UV spectrophotometry and (1)H NMR (n = 3). Data were analyzed by one-way ANOVA and Tukey's test ( α = 0.05). Results. Both compounds inhibited S. mutans growth, with CHX being most effective (P < 0.05). Control resin had the lowest FS and E values, followed by ACY and CHX, with statistical difference between control and CHX groups for both mechanical properties (P < 0.05). The 24 h compound release rates were ACY: 1.33 μg/mL and CHX: 1.92 μg/mL. (1)H NMR spectra suggests that both compounds remained stable after being released in water. Conclusion. The present findings indicate that anthocyanins might be used as a natural antibacterial agent in resin based materials.

Identifiers

PMID24693287
PMCPMC3947769
OpenAlexW2008554123

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.