Evidence map›Paper›PMID 24693236›Full record

ArticleTheScientificWorldJournal2014

Effect of fluorosis on liver cells of VC deficient and wild type mice.

Wei Wei, Yan Jiao, Yonghui Ma, John M Stuart, Xiudian Li, Fusheng Zhao, Lishi Wang, Dianjun Sun, Weikuan Gu

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Selenium attenuates apoptosis and p-AMPK expressions in fluoride-induced NRK-52E cells.Environmental science and pollution research international · 2019
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Wei WeiCenter for Endemic Disease Control, Centers for Disease Control and Prevention, Institute of Endemic Fluorosis Disease, Harbin Medical University, Harbin, Heilongjiang 150081, China ; Departments of Orthopaedic Surgery and BME, Campbell Clinic, and Pathology, University of Tennessee Health Science Center (UTHSC), 956 Court Avenue, Memphis, TN 38163, USA.
Yan JiaoDepartments of Orthopaedic Surgery and BME, Campbell Clinic, and Pathology, University of Tennessee Health Science Center (UTHSC), 956 Court Avenue, Memphis, TN 38163, USA ; Mudanjiang Medical College, Mudanjiang, Heilongjiang 157001, China.
Yonghui MaDepartments of Orthopaedic Surgery and BME, Campbell Clinic, and Pathology, University of Tennessee Health Science Center (UTHSC), 956 Court Avenue, Memphis, TN 38163, USA.
John M StuartDivision of Connective Tissues Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA ; Department of Veterans Affairs Medical Center, Memphis, TN 38104, USA.
Xiudian LiDepartment of Nephrology, Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, China.
Fusheng ZhaoDepartments of Orthopaedic Surgery and BME, Campbell Clinic, and Pathology, University of Tennessee Health Science Center (UTHSC), 956 Court Avenue, Memphis, TN 38163, USA ; Mudanjiang Medical College, Mudanjiang, Heilongjiang 157001, China.
Lishi WangDepartments of Orthopaedic Surgery and BME, Campbell Clinic, and Pathology, University of Tennessee Health Science Center (UTHSC), 956 Court Avenue, Memphis, TN 38163, USA.
Dianjun SunCenter for Endemic Disease Control, Centers for Disease Control and Prevention, Institute of Endemic Fluorosis Disease, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Weikuan GuDepartments of Orthopaedic Surgery and BME, Campbell Clinic, and Pathology, University of Tennessee Health Science Center (UTHSC), 956 Court Avenue, Memphis, TN 38163, USA.ORCID 0000-0003-1112-8088
University of Tennessee Health Science Center · USHarbin Medical University · CNHeilongjiang University of Chinese Medicine · CN

Funding

MUTATION SCREENING OF SKELETAL DISEASE MOUSE MODELSR01AR051190 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI GU, WEIKUAN · 2004 to 2007
$1.1M
NIAMS NIH HHS R01 AR051190NIAMS NIH HHS R01 AR51190
6 · The paper itself

Abstract

For decades, mouse and other rodents have been used for the study of oxidative or related studies such as the effect of fluoride. It is known that rodents normally synthesize their own vitamin C (VC) due to the presence of a key enzyme in ascorbic acid synthesis, l-gulono-lactone-γ-oxidase (Gulo), while humans do not have the capacity of VC synthesis due to the deletion of most parts of the GULO gene. The spontaneous fracture (sfx) mouse recently emerged as a model for study of VC deficiency. We investigated the effect of fluoride on liver cells from wild type Balb/c and sfx mice. We found that activities of SOD, GPx, and CAT were reduced in both wild type and sfx mice; however, the amount of reduction in the sfx cells is more than that in Balb/c cells. In addition, while both cells increased MDA, the increase in the sfx cells is greater than that in Balb/c cells. Gene networks of Sod, Gpx, and Cat in the liver of humans and mice are also different. Our study suggests that reaction to fluoride in vitamin C deficient mice might be different from that of wild type mice.

Indexed as

AnimalsAscorbic Acid DeficiencyCells, CulturedFluoridesFluorosis, DentalHepatocytesMiceMice, Inbred BALB CMice, KnockoutOxidative StressReactive Oxygen SpeciesFluoridesReactive Oxygen Species

Identifiers

PMID24693236
PMCPMC3947854
OpenAlexW2044885302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.