ArticleInfectious diseases in obstetrics and gynecology2014
High rate of chronic villitis in placentas of pregnancies complicated by influenza A/H1N1 infection.
Article in Infectious diseases in obstetrics and gynecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Viral threats to pregnancy: Global health risks in the era of pandemics.Advances in virus research · 2026Review
- Association between SARS-CoV-2 infection during pregnancy and placental pathology assessed by histology and gene expression.Pregnancy (Hoboken, N.J.) · 2025Article
- Maternal-Fetal Connections in Prenatal Respiratory Disease: Time to Address Intrauterine Inflammation.American journal of respiratory and critical care medicine · 2024Article
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- Obstetric and neonatal outcomes after SARS-CoV-2 infection in the first trimester of pregnancy: A prospective comparative study.The journal of obstetrics and gynaecology research · 2022Observational
- Placental deficiency during maternal SARS-CoV-2 infection.Placenta · 2022Article
- COVID-19 in pregnancy: What we know from the first year of the pandemic.Biochimica et biophysica acta. Molecular basis of disease · 2021Review
- Placenta histopathology in SARS-CoV-2 infection: analysis of a consecutive series and comparison with control cohorts.Virchows Archiv : an international journal of pathology · 2021Article
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- Maternal immune responses and obstetrical outcomes of pregnant women with COVID-19 and possible health risks of offspring.Journal of reproductive immunology · 2021Review
- Villitis of Unknown Etiology in the Placenta of a Pregnancy Complicated by COVID-19.Turk patoloji dergisi · 2021Article
- Role of Inflammation in Virus Pathogenesis during Pregnancy.Journal of virology · 2020Review
- Article
- Hormonal Regulation of Physiology, Innate Immunity and Antibody Response to H1N1 Influenza Virus Infection During Pregnancy.Frontiers in immunology · 2018Review
- H1N1 influenza virus infection results in adverse pregnancy outcomes by disrupting tissue-specific hormonal regulation.PLoS pathogens · 2017Article
- Influenza pathogenicity during pregnancy in women and animal models.Seminars in immunopathology · 2016Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPandemic influenza A/H1N1 infection during pregnancy has a negative impact on several aspects of pregnancy outcome. As yet, no elucidating mechanism has been revealed for these effects. We investigated whether placentas of pregnancies complicated by 2009 influenza A/H1N1 infection demonstrated an increased rate of chronic villitis and whether this villitis was caused by influenza virus.
methodsWe performed a cohort study on 145 pregnant outpatients during the 2009-2010 influenza A H1N1 pandemic. The placentas of patients with influenza infection were examined for histologic signs of chronic villitis. In case of villitis, polymerase chain reaction (PCR) on influenza virus was performed on placental tissue.
results29 patients had influenza infection. Placentas of 15 of these patients were collected and examined. In 7 cases (47%) chronic villitis was detected. Placental weight and birth weight of the neonates did not differ between cases with and without chronic villitis. In all cases PCR was negative for influenza.
conclusionIn our series, chronic villitis was present in a high proportion of placentas of pregnancies complicated by 2009 influenza A/H1N1 infection. We could not demonstrate the presence of influenza virus in placental tissue.
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