ArticleJournal of stem cells & regenerative medicine2012
Derivation of es Cells From Early Stage Preimplantation Embryos and Characterisation of their Cardiac Differentiation Potential in Mice.
Article in Journal of stem cells & regenerative medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Establishment of porcine nuclear transfer-derived embryonic stem cells using induced pluripotent stem cells as donor nuclei.The Journal of reproduction and development · 2020Article
- ATP Binding Cassette Sub-family Member 2 (ABCG2) and Xenobiotic Exposure During Early Mouse Embryonic Stem Cell Differentiation.Birth defects research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most murine embryonic stem cell lines have been derived from the inner cell mass of blastocysts and extensively studied in different aspects including generation of organ specific cells. However, no detailed studies have been made on cardiac specific gene expression, immunocytochemical and electrophysiological characterisation of cardiomyocytes generated from early stage (preimplantation) embryo derived embryonic stem cells in mice. In the present study, new embryonic stem cell lines were derived from early stage preimplanatation embryos in mice. In vitro differentiation of such cell lines readily generated cardiomyocytes, which expressed different cardiac specific genes in a temporally regulated manner as well as cardiac cells specific proteins. This is probably the first report, which showed the temporal pattern of cardiac specific genes as well as protein expression in cardiac cells generated from in vitro differentiation of preimplantation embryo derived ES cells.
Indexed as
Identifiers
24693188PMC3908304W2187371320What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.