Evidence map›Paper›PMID 24692840›Full record

ArticleProgress in polymer science2007

Emerging Applications of Polymersomes in Delivery: from Molecular Dynamics to Shrinkage of Tumors.

Dennis E Discher, Vanessa Ortiz, Goundla Srinivas, Michael L Klein, Younghoon Kim, David Christian, Shenshen Cai, Peter Photos, Fariyal Ahmed

Abstract read
In one paragraph

Article in Progress in polymer science, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Vaccine Adjuvants and Delivery Systems: A Comprehensive Review.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Review
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  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Constructing artificial respiratory chain in polymer compartments: Insights into the interplay betweenProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. Article
  12. Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  13. Potential applications of engineered nanoparticles in medicine and biology: an update.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2018
    Review
  14. Article
  15. Article
  16. Review
  17. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dennis E DischerNanoBio Polymers Lab, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Vanessa OrtizCenter for Molecular Modeling-Dept. of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Goundla SrinivasCenter for Molecular Modeling-Dept. of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Michael L KleinCenter for Molecular Modeling-Dept. of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Younghoon KimNanoBio Polymers Lab, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
David ChristianNanoBio Polymers Lab, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Shenshen CaiNanoBio Polymers Lab, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Peter PhotosNanoBio Polymers Lab, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Fariyal AhmedNanoBio Polymers Lab, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

Funding

SPECTRIN EXTENSIBILITY and CD47 CONNECTIONS &FUNCTIONR01HL062352 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, DENNIS E. · 1999 to 2012
$3.3M
Carrier Shape Matters: Filomicelles, Long-circulation, and the EPR effectR01EB007049 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, DENNIS E. · 2006 to 2014
$2.8M
Understanding HIV escape using atomic force microscopyR21AI087516 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI DISCHER, DENNIS E., FINKEL, TERRI H · 2010 to 2011
$474k
Myocytes sense substrate stiffness - New materialsR21EB004489 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, DENNIS E. · 2005 to 2006
$415k
AFM(T) + FLUORESCENCE MEASUREMENTS ON SINGLE MOLECULESS10RR022575 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, DENNIS E. · 2007 to 2007
$382k
Matrix-induced Myogenesis & Pharmaco-Screens of MSCsR21AR056128 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, DENNIS E. · 2008 to 2009
$364k
CD47-Display on NanomaterialsR21EB003164 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, DENNIS E. · 2003 to 2004
$360k
Worm-like Micelles for Targeted Delivery and ImagingR21EB004000 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, DENNIS E. · 2004 to 2005
$348k
NCRR NIH HHS S10 RR022575NHLBI NIH HHS R01 HL062352NIAID NIH HHS R21 AI087516NIAMS NIH HHS R21 AR056128NIBIB NIH HHS R01 EB007049NIBIB NIH HHS R21 EB003164NIBIB NIH HHS R21 EB004000NIBIB NIH HHS R21 EB004489
6 · The paper itself

Abstract

Polymersomes are self-assembled shells of amphiphilic block copolymers that are currently being developed by many groups for fundamental insights into the nature of self-assembled states as well as for a variety of potential applications. While recent reviews have highlighted distinctive properties - particularly stability - that are strongly influenced by both copolymer type and polymer molecular weight, here we first review some of the more recent developments in computational molecular dynamics (MD) schemes that lend insight into assembly. We then review polymersome loading, in vivo stealthiness, degradation-based disassembly for controlled release, and even tumor-shrinkage in vivo. Comparisons of polymersomes with viral capsids are shown to encompass and inspire many aspects of current designs.

Indexed as

amphiphileblock copolymerscontrolled releaseliposomesnanoparticles

Identifiers

PMID24692840
PMCPMC3969797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.