ArticlemBio2014
Symbiotic adaptation drives genome streamlining of the cyanobacterial sponge symbiont "Candidatus Synechococcus spongiarum".
Article in mBio, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 87 citations in OpenAlex.
- Diel transcriptional dynamics of a marine sponge and its microbiome in a natural environment.Animal microbiome · 2026Article
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- Survival strategies for the microbiome in a vent-dwelling glass sponge from the middle Okinawa Trough.Frontiers in microbiology · 2025Article
- Unveiling microbial guilds and symbiotic relationships in Antarctic sponge microbiomes.Scientific reports · 2024Article
- Lineage-specific energy and carbon metabolism of sponge symbionts and contributions to the host carbon pool.The ISME journal · 2022Article
- Prevalence, complete genome, and metabolic potentials of a phylogenetically novel cyanobacterial symbiont in the coral-killing sponge, Terpios hoshinota.Environmental microbiology · 2022Article
- A Large-Scale Genome-Based Survey of Acidophilic Bacteria Suggests That Genome Streamlining Is an Adaption for Life at Low pH.Frontiers in microbiology · 2022Article
- Genome Reduction and Secondary Metabolism of the Marine Sponge-Associated CyanobacteriumMarine drugs · 2021Article
- Analysis of bacterial communities in sponges and coral inhabiting Red Sea, using barcoded 454 pyrosequencing.Saudi journal of biological sciences · 2021Article
- Variability in Host Specificity and Functional Potential of Antarctic Sponge-Associated Bacterial Communities.Frontiers in microbiology · 2021Article
- Bacteria Isolated From the Antarctic SpongeFrontiers in microbiology · 2021Article
- Viral ecogenomics across the Porifera.Microbiome · 2020Article
- Natural Products Repertoire of the Red Sea.Marine drugs · 2020Review
- Characterization of a sponge microbiome using an integrative genome-centric approach.The ISME journal · 2020Article
- Characterizing the microbiomes of Antarctic sponges: a functional metagenomic approach.Scientific reports · 2020Article
- Genomic Insights Into the Lifestyles of Thaumarchaeota Inside Sponges.Frontiers in microbiology · 2020Article
- Comparative Genomics Reveals Metabolic Specificity ofMicroorganisms · 2019Article
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- Comparative Genomics Reveals Ecological and Evolutionary Insights into Sponge-AssociatedmSystems · 2019Article
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
"Candidatus Synechococcus spongiarum" is a cyanobacterial symbiont widely distributed in sponges, but its functions at the genome level remain unknown. Here, we obtained the draft genome (1.66 Mbp, 90% estimated genome recovery) of "Ca. Synechococcus spongiarum" strain SH4 inhabiting the Red Sea sponge Carteriospongia foliascens. Phylogenomic analysis revealed a high dissimilarity between SH4 and free-living cyanobacterial strains. Essential functions, such as photosynthesis, the citric acid cycle, and DNA replication, were detected in SH4. Eukaryoticlike domains that play important roles in sponge-symbiont interactions were identified exclusively in the symbiont. However, SH4 could not biosynthesize methionine and polyamines and had lost partial genes encoding low-molecular-weight peptides of the photosynthesis complex, antioxidant enzymes, DNA repair enzymes, and proteins involved in resistance to environmental toxins and in biosynthesis of capsular and extracellular polysaccharides. These genetic modifications imply that "Ca. Synechococcus spongiarum" SH4 represents a low-light-adapted cyanobacterial symbiont and has undergone genome streamlining to adapt to the sponge's mild intercellular environment. IMPORTANCE Although the diversity of sponge-associated microbes has been widely studied, genome-level research on sponge symbionts and their symbiotic mechanisms is rare because they are unculturable. "Candidatus Synechococcus spongiarum" is a widely distributed uncultivated cyanobacterial sponge symbiont. The genome of this symbiont will help to characterize its evolutionary relationship and functional dissimilarity to closely related free-living cyanobacterial strains. Knowledge of its adaptive mechanism to the sponge host also depends on the genome-level research. The data presented here provided an alternative strategy to obtain the draft genome of "Ca. Synechococcus spongiarum" strain SH4 and provide insight into its evolutionary and functional features.
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