ArticleEMBO reports2014
Saccharomyces cerevisiae Rif1 cooperates with MRX-Sae2 in promoting DNA-end resection.
Article in EMBO reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- The epistatic relationship of Drosophila melanogaster CtIP and Rif1 in homology-directed repair of DNA double-strand breaks.G3 (Bethesda, Md.) · 2024Article
- Checkpoint phosphorylation sites on budding yeast Rif1 protect nascent DNA from degradation by Sgs1-Dna2.PLoS genetics · 2023Article
- Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction.Nature communications · 2021Article
- ChECing out Rif1 action in freely cycling cells.Current genetics · 2019Review
- Both a Unique Motif at the C Terminus and an N-Terminal HEAT Repeat Contribute to G-Quadruplex Binding and Origin Regulation by the Rif1 Protein.Molecular and cellular biology · 2019Article
- Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks.Microbial cell (Graz, Austria) · 2018Review
- Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends.Nature structural & molecular biology · 2017Article
- Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1).Scientific reports · 2017Article
- Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation.EMBO reports · 2017Article
- Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication.PLoS genetics · 2016Article
- Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.G3 (Bethesda, Md.) · 2016Article
- TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres.Molecular cell · 2016Article
- Rif1: A Conserved Regulator of DNA Replication and Repair Hijacked by Telomeres in Yeasts.Frontiers in genetics · 2016Article
- Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process.Nature communications · 2015Article
- A new Riff: Rif1 eats its cake and has it too.EMBO reports · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diverse roles in DNA metabolism have been envisaged for budding yeast and mammalian Rif1. In particular, yeast Rif1 is involved in telomere homeostasis, while its mammalian counterpart participates in the cellular response to DNA double-strand breaks (DSBs). Here, we show that Saccharomyces cerevisiae Rif1 supports cell survival to DNA lesions in the absence of MRX or Sae2. Furthermore, it contributes to the nucleolytic processing (resection) of DSBs. This Rif1-dependent control of DSB resection becomes important for DSB repair by homologous recombination when resection activities are suboptimal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.