ArticleThe Plant cell2014
Arabidopsis Cuticular Wax Biosynthesis Is Negatively Regulated by the DEWAX Gene Encoding an AP2/ERF-Type Transcription Factor.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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Who cites it
92 citing papers in PubMed, 195 citations in OpenAlex.
- Cuticular Waxes in Altered Environments and Their Role in Leaf Water Loss Dynamics.Plant, cell & environment · 2026Review
- Transcriptome-Based Identification ofPlants (Basel, Switzerland) · 2026Article
- FERONIA defines intact tissue boundaries through cuticle development.Nature communications · 2026Article
- Transcriptional control of cuticle formation during development.Journal of experimental botany · 2026Review
- AaSIZ1-Mediated SUMOylation of AaMYB31 Positively Regulates Freezing Tolerance in Actinidia arguta.Plant biotechnology journal · 2026Article
- Identification ofPlants (Basel, Switzerland) · 2026Article
- The Role and Regulatory Mechanisms of Cuticular Wax in Crop Stress Tolerance and Yield.Plants (Basel, Switzerland) · 2026Review
- Dual Regulation of Cuticle and Cell Wall Biosynthesis by BnaC9.MYB46 Confers Drought Tolerance in Brassica napus.Plant biotechnology journal · 2025Article
- Genome-wide characterization of the Eceriferum (CER) gene family in barley (Hordeum vulgare L.).Scientific reports · 2025Article
- Water stress reduces cellulose deposition in the cell wall and increases wax content, resulting in decreased fiber quality.Frontiers in plant science · 2025Article
- Wheat WW Domain-Containing Protein TaCFL1 Negatively Regulates Cuticular Wax Biosynthesis.International journal of molecular sciences · 2024Article
- Wheat Transcription Factor TaMYB60 Modulates Cuticular Wax Biosynthesis by ActivatingInternational journal of molecular sciences · 2024Article
- Wheat MIXTA-like Transcriptional Activators Positively Regulate Cuticular Wax Accumulation.International journal of molecular sciences · 2024Article
- Fine mapping and identification of the bright green leaf geneFrontiers in plant science · 2024Article
- Fine Mapping and Identification of a Candidate Gene for the Glossy Green Trait in Cabbage (Plants (Basel, Switzerland) · 2023Article
- An ancestral role for 3-KETOACYL-COA SYNTHASE3 as a negative regulator of plant cuticular wax synthesis.The Plant cell · 2023Article
- AnInternational journal of molecular sciences · 2023Article
- Article
- How Does Stomatal Density and Residual Transpiration Contribute to Osmotic Stress Tolerance?Plants (Basel, Switzerland) · 2023Review
- Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aerial parts of plants are protected from desiccation and other stress by surface cuticular waxes. The total cuticular wax loads and the expression of wax biosynthetic genes are significantly downregulated in Arabidopsis thaliana under dark conditions. We isolated Decrease Wax Biosynthesis (DEWAX), which encodes an AP2/ERF-type transcription factor that is preferentially expressed in the epidermis and induced by darkness. Disruption of DEWAX leads to an increase in total leaf and stem wax loads, and the excess wax phenotype of dewax was restored to wild type levels in complementation lines. Moreover, overexpression of DEWAX resulted in a reduction in total wax loads in leaves and stems compared with the wild type and altered the ultrastructure of cuticular layers. DEWAX negatively regulates the expression of alkane-forming enzyme, long-chain acyl-CoA synthetase, ATP citrate lyase A subunit, enoyl-CoA reductase, and fatty acyl-CoA reductase, and chromatin immunoprecipitation analysis suggested that DEWAX directly interacts with the promoters of wax biosynthesis genes. Cuticular wax biosynthesis is negatively regulated twice a day by the expression of DEWAX, throughout the night and at stomata closing. Significantly higher levels (10- to 100-fold) of DEWAX transcripts were found in leaves than in stems, suggesting that DEWAX-mediated transcriptional repression may be an additional mechanism contributing to the different total wax loads in leaves and stems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.