Evidence map›Paper›PMID 24692351›Full record

ReviewPhysiological reviews2014

Thyroid hormone regulation of metabolism.

Rashmi Mullur, Yan-Yun Liu, Gregory A Brent

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Physiological reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,050 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,050citing papers in PubMed, 7 pooled it
62.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,050 citing papers in PubMed, 7 syntheses or guidelines pooled it, 2,286 citations in OpenAlex.

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  14. Sex and age at exposure influenceBiology of sex differences · 2026
    Article
  15. METTL18 is Required for Developmental, Metabolic, and Endocrine Regulation of Mammalian Growth.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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990 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rashmi Mullur
Yan-Yun Liu
Gregory A Brent
VA Greater Los Angeles Healthcare System · US

Funding

Thyroid Hormone Receptor Isoform-Specific ActionsR01DK098576 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRENT, GREGORY A · 2014 to 2017
$1.3M
ROLE OF PROGESTERONE RECEPTOR RATIO IN BREAST CANCERF32CA090073 · NCI · UNIVERSITY OF COLORADO DENVER · PI JACOBSEN, BRITTA M · 2001 to 2003
$127k
NCI NIH HHS F32 CA090073NIDDK NIH HHS R01 DK098576NIDDK NIH HHS R01 DK98576
6 · The paper itself

Abstract

Thyroid hormone (TH) is required for normal development as well as regulating metabolism in the adult. The thyroid hormone receptor (TR) isoforms, α and β, are differentially expressed in tissues and have distinct roles in TH signaling. Local activation of thyroxine (T4), to the active form, triiodothyronine (T3), by 5'-deiodinase type 2 (D2) is a key mechanism of TH regulation of metabolism. D2 is expressed in the hypothalamus, white fat, brown adipose tissue (BAT), and skeletal muscle and is required for adaptive thermogenesis. The thyroid gland is regulated by thyrotropin releasing hormone (TRH) and thyroid stimulating hormone (TSH). In addition to TRH/TSH regulation by TH feedback, there is central modulation by nutritional signals, such as leptin, as well as peptides regulating appetite. The nutrient status of the cell provides feedback on TH signaling pathways through epigentic modification of histones. Integration of TH signaling with the adrenergic nervous system occurs peripherally, in liver, white fat, and BAT, but also centrally, in the hypothalamus. TR regulates cholesterol and carbohydrate metabolism through direct actions on gene expression as well as cross-talk with other nuclear receptors, including peroxisome proliferator-activated receptor (PPAR), liver X receptor (LXR), and bile acid signaling pathways. TH modulates hepatic insulin sensitivity, especially important for the suppression of hepatic gluconeogenesis. The role of TH in regulating metabolic pathways has led to several new therapeutic targets for metabolic disorders. Understanding the mechanisms and interactions of the various TH signaling pathways in metabolism will improve our likelihood of identifying effective and selective targets.

Indexed as

Energy MetabolismSignal TransductionAnimalsBody WeightCarbohydrate MetabolismCholesterolHumansThermogenesisThyroid GlandThyroid HormonesTriglyceridesCholesterolThyroid HormonesTriglycerides

Identifiers

PMID24692351
PMCPMC4044302
OpenAlexW1966824338

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.