ArticleVirus genes2014
Genetic characterization of an isolate of canine distemper virus from a Tibetan Mastiff in China.
Article in Virus genes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Epidemiological, Clinical, and Molecular Insights into Canine Distemper Virus in the Mekong Delta Region of Vietnam.Viruses · 2025Article
- Immunogenicity and protective efficacy of a novel bacterium-like particle-based vaccine displaying canine distemper virus antigens in mice and dogs.Microbiology spectrum · 2024Article
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- Approaches to identify canine distemper virus with neurological symptoms on the basis of molecular characterization of hemagglutinin and fusion genes.Virus genes · 2023Article
- Structure and supramolecular organization of the canine distemper virus attachment glycoprotein.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Neuropathologic and molecular aspects of a canine distemper epizootic in red foxes in Germany.Scientific reports · 2022Article
- Article
- Complete genomic sequencing of canine distemper virus with nanopore technology during an epizootic event.Scientific reports · 2022Article
- Review
- Molecular surveillance of canine distemper virus in diarrhoetic puppies in northeast China from May 2014 to April 2015.The Journal of veterinary medical science · 2018Article
- Article
- Article
- Outbreak and genotyping of canine distemper virus in captive Siberian tigers and red pandas.Scientific reports · 2017Article
- Isolation and phylogenetic analysis of canine distemper virus among domestic dogs in Vietnam.The Journal of veterinary medical science · 2017Article
- Canine distemper virus isolated from a monkey efficiently replicates on Vero cells expressing non-human primate SLAM receptors but not human SLAM receptor.BMC veterinary research · 2016Article
- Isolation and sequence analysis of a canine distemper virus from a raccoon dog in Jilin Province, China.Virus genes · 2015Article
- Isolation and phylogenetic characterization of Canine distemper virus from India.Virusdisease · 2015Article
- First isolation of new canine parvovirus 2a from Tibetan mastiff and global analysis of the full-length VP2 gene of canine parvoviruses 2 in China.International journal of molecular sciences · 2014Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine distemper (CD) is a highly contagious, often fatal, multisystemic, and incurable disease in dogs and other carnivores, which is caused by canine distemper virus (CDV). Although vaccines have been used as the principal means of controlling the disease, CD has been reported in vaccinated animals. The hemoagglutinin (H) protein is one of the most important antigens for inducing protective immunity against CD, and antigenic variation of recent CDV strains may explain vaccination failure. In this study, a new CDV isolate (TM-CC) was obtained from a Tibetan Mastiff that died of distemper, and its genome was characterized. Phylogenetic analysis of the H gene revealed that the CDV-TM-CC strain is unique among 20 other CDV strains and can be classified into the Asia-1 group with the Chinese strains, Hebei and HLJ1-06, and the Japanese strain, CYN07-hV. The H gene of CDV-TM-CC shows low identity (90.4 % nt and 88.9 % aa) with the H gene of the classical Onderstepoort vaccine strain, which may explain the inability of the Tibetan Mastiff to mount a protective immune response. We also performed a comprehensive phylogenetic analysis of the N, P, and F protein sequences, as well as potential N-glycosylation sites and cysteine residues. This analysis shows that an N-glycosylation site at aa 108-110 within the F protein of CDV-TM-CC is specific for the wild-type strains (5804P, A75/17, and 164071) and the Asia-1 group strains, and may be another important factor for the poor immune response. These results provide important information for the design of CD vaccines in the China region and elsewhere.
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