ArticleMolecular medicine reports2014
Autophagy in human articular chondrocytes is cytoprotective following glucocorticoid stimulation.
Article in Molecular medicine reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- The Effect of Physical, Biochemical, and Electrical Culture Conditions on Articular Chondrocytes Used for Cartilage Tissue Engineering: A Narrative Review.International journal of molecular sciences · 2026Review
- Dexamethasone: a double-edged sword in the treatment of osteoarthritis.Scientific reports · 2025Article
- Enhancing retention and permeation of rapamycin for osteoarthritis therapy using a two-stage drug delivery system.Materials today. Bio · 2024Article
- Chondrotoxicity of Intra-Articular Injection Treatment: A Scoping Review.International journal of molecular sciences · 2024Article
- Zwitterionic polymer-dexamethasone conjugates penetrate and protect cartilage from inflammation.Materials today. Bio · 2024Article
- Extracellular Vesicles Derived from Auricular Chondrocytes Facilitate Cartilage Differentiation of Adipose-Derived Mesenchymal Stem Cells.Aesthetic plastic surgery · 2023Article
- Downregulation of Sox8 mediates monosodium urate crystal-induced autophagic impairment of cartilage in gout arthritis.Cell death discovery · 2023Article
- Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy.Cell death & disease · 2022Article
- New insights into the interplay between autophagy and cartilage degeneration in osteoarthritis.Frontiers in cell and developmental biology · 2022Review
- Articular chondrocyte-derived extracellular vesicles promote cartilage differentiation of human umbilical cord mesenchymal stem cells by activation of autophagy.Journal of nanobiotechnology · 2020Article
- Dexamethasone: chondroprotective corticosteroid or catabolic killer?European cells & materials · 2019Review
- Effects of autophagy on apoptosis of articular chondrocytes in adjuvant arthritis rats.Journal of cellular and molecular medicine · 2019Article
- Dose-related histopathology and bone remodeling characteristics of the knee articular cartilage and subchondral bone induced by glucocorticoids in rats.Experimental and therapeutic medicine · 2019Article
- Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis.Frontiers in physiology · 2018Review
- The role of autophagy in allergic inflammation: a new target for severe asthma.Experimental & molecular medicine · 2016Article
- BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death.Oncotarget · 2016Article
- Monosodium Urate Crystal-Induced Chondrocyte Death via Autophagic Process.International journal of molecular sciences · 2015Article
- Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis.International journal of molecular sciences · 2015Review
- The Effect of Intra-articular Corticosteroids on Articular Cartilage: A Systematic Review.Orthopaedic journal of sports medicine · 2015Review
- mTOR: a potential therapeutic target in osteoarthritis?Drugs in R&D · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For the past 60 years, glucocorticosteroid (GC) drugs, including prednisone and dexamethasone (Dex), have been used for the treatment of early stage osteoarthritis (OA). However, multiple administration of GCs may destroy the articular cartilage. It has been previously reported that GC treatment may also lead to the initiation of autophagy, which is an essential mechanism for cell homeostasis and survival. Rapamycin (Rapa), an inhibitor of the mammalian target of Rapamycin, may cause a degeneration-associated pathology in organs and induce autophagy in a variety of cell types, which has been applied in the treatment of experimental OA. A previous study by our group observed that GC apparently increases the apoptosis of chondrocytes, resulting in the inhibition of extracellular matrix synthesis. Therefore, the present study aimed to further examine the effects of autophagy in chondrocytes under GC treatment and to verify the molecular mechanisms involved in the cytoprotective role of Rapa. Short-term GC treatment did not significantly inhibit chondrocyte viability, while cell autophagy was increased. In addition, upregulation of autophagy by Rapa prevented the expression of apoptosis-associated genes and improved cell activity. In conclusion, the present study revealed that increased autophagy is an adaptive response to protect chondrocytes from short‑term GC exposure, whereas prolonged GC treatment decreases autophagy and increases apoptosis in vitro. Upregulation of autophagy by Rapa may protect chondrocytes against the adverse effect induced by GC.
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