ReviewThe Journal of clinical investigation2014
Obstructive sleep apnea and insight into mechanisms of sympathetic overactivity.
Review in The Journal of clinical investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 6 syntheses or guidelines pooled it, 152 citations in OpenAlex.
- Effect of obstructive sleep apnea on postoperative delirium: a system review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- An umbrella review of systematic reviews and meta-analyses of observational investigations of obstructive sleep apnea and health outcomes.Sleep & breathing = Schlaf & Atmung · 2022Pooled it
- Neuroadrenergic activation in obstructive sleep apnoea syndrome: a new selected meta-analysis - revisited.Journal of hypertension · 2022Pooled it
- Soluble P-selectin levels in patients with obstructive sleep apnea: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Pooled it
- Does continuous positive airway pressure therapy benefit patients with coronary artery disease and obstructive sleep apnea? A systematic review and meta-analysis.Clinical cardiology · 2021Pooled it
- The role of continuous positive airway pressure in blood pressure control for patients with obstructive sleep apnea and hypertension: a meta-analysis of randomized controlled trials.Journal of clinical hypertension (Greenwich, Conn.) · 2015Pooled it
- Trial
- Clinical safety and hemodynamic, cardiac autonomic and inflammatory responses to a single session of inspiratory muscle training in obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2022Trial
- Inorganic nitrate supplementation attenuates peripheral chemoreflex sensitivity but does not improve cardiovagal baroreflex sensitivity in older adults.American journal of physiology. Heart and circulatory physiology · 2018Trial
- A narrative review on the interplay between interstitial lung disease and obstructive sleep apnea: Mechanisms, clinical implications, and management strategies.Sleep medicine: X · 2026Review
- Changes in Body Mass Index Following Pediatric Tonsillectomy for Obstructive Sleep Apnea.Cureus · 2026Article
- Morning Headaches as a Specific Obstructive Sleep Apnea Characteristic in a Large Sleep Clinic Population.Life (Basel, Switzerland) · 2026Article
- From classic to cutting-edge: technological approaches to respiratory physiological signals in assessing sleep-disordered breathing.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Review
- Article
- SDANN May Be Used as a Screening Factor of Obstructive Sleep Apnea in Adult Individuals.BioMed research international · 2026Article
- Detection and severity assessment of obstructive sleep apnea according to deep learning of single-lead electrocardiogram signals.Journal of sleep research · 2025Article
- Deep Learning for Obstructive Sleep Apnea Detection and Severity Assessment: A Multimodal Signals Fusion Multiscale Transformer Model.Nature and science of sleep · 2025Article
- Comprehensive Insights into Mechanisms for Ventricular Remodeling in Right Heart Failure.Reviews in cardiovascular medicine · 2024Review
- Napping and Obesity in Adults - What do we Know?Current diabetes reports · 2024Review
- Chronic intermittent hypoxia facilitates the development of angiotensin II-induced abdominal aortic aneurysm in male mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Nearly two decades ago, we evaluated ten patients with obstructive sleep apnea (OSA). We determined that alarming nocturnal oscillations in arterial pressure and sympathetic nerve activity (SNA) were caused by regulatory coupling and neural interactions among SNA, apnea, and ventilation. Patients with OSA exhibited high levels of SNA when awake, during normal ventilation, and during normoxia, which contributed to hypertension and organ damage. Additionally, we achieved a beneficial and potentially lifesaving reduction in SNA through the application of continuous positive airway pressure (CPAP), which remains a primary therapeutic approach for patients with OSA. With these results in hindsight, we herein discuss three concepts with functional and therapeutic relevance to the integrative neurobiology of autonomic cardiovascular control and to the mechanisms involved in excessive sympathoexcitation in OSA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.