Evidence map›Paper›PMID 24691423›Full record

ArticleBritish journal of cancer2014

Tumour-infiltrating CD4(+) and CD8(+) lymphocytes as predictors of clinical outcome in glioma.

S Han, C Zhang, Q Li, J Dong, Y Liu, Y Huang, T Jiang, A Wu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 218 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
218citing papers in PubMed, 3 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

218 citing papers in PubMed, 3 syntheses or guidelines pooled it, 356 citations in OpenAlex.

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  7. CD163 Dominance Within Macrophages/Microglia Reflects a Favorable Prognosis in Patients With Glioblastoma.Neuropathology : official journal of the Japanese Society of Neuropathology · 2026
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158 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

S HanDepartment of Neurosurgery, The First Hospital of China Medical University, Nanjing street 155, Heping district, Shenyang 110001, China.
C ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
Q LiDepartment of Pathology, China Medical University, Shenyang 110001, China.
J DongDepartment of Neurosurgery, The First Hospital of China Medical University, Nanjing street 155, Heping district, Shenyang 110001, China.
Y LiuDepartment of Neurosurgery, The First Hospital of China Medical University, Nanjing street 155, Heping district, Shenyang 110001, China.
Y HuangDepartment of Neurosurgery, The First Hospital of China Medical University, Nanjing street 155, Heping district, Shenyang 110001, China.
T JiangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
A WuDepartment of Neurosurgery, The First Hospital of China Medical University, Nanjing street 155, Heping district, Shenyang 110001, China.
China Medical University · CNBeijing Tian Tan Hospital · CNCapital Medical University · CNFirst Hospital of China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundT lymphocyte infiltration has been detected in glioma, although its significance remains unclear. The purpose of the present study was to explore the prognostic value of CD4(+) and CD8(+) tumour-infiltrating lymphocytes (TILs) in glioma, and the prognostic value of infiltrating Forkhead box protein 3 (FoxP3(+)) regulatory T cells were also investigated.

methodsCD4(+), FoxP3(+) and CD8(+) TILs were assessed by immunohistochemical staining of tissue microarray cores from 284 gliomas. Kaplan-Meier analysis and Cox proportional hazards models were used to examine the survival function of these TILs in 90 glioblastoma patients.

resultsThe number of CD8(+) TILs was inversely correlated with tumour grade (P=0.025), whereas the number of CD4(+) TILs was positively correlated with tumour grade (P=0.002). FoxP3(+) TILs were only observed in glioblastomas, but not in low-grade astrocytomas or oligodendroglial tumours. Among patients with glioblastoma, none of CD4(+) TILs, FoxP3(+) TILs and CD8(+) TILs alone was significantly associated with patient prognosis. However, the presence of high CD4(+) and low CD8(+) TIL levels was an independent predictor of poor progress-free survival (multivariate hazard ratio (HR) 1.618, 95% confidence interval (CI) 1.245-2.101, P<0.001) and poor overall survival (multivariate HR 1.508, 95% CI 1.162-1.956, P=0.002). Moreover, pseudoprogression was more often found in patients with high CD4(+) TILs and high CD8(+) TILs.

conclusionsThe combination of CD4(+) and CD8(+) TILs is a predictor of clinical outcome in glioblastoma patients, and a high level of CD4(+) TILs combined with low CD8(+) TILs was associated with unfavourable prognosis.

Indexed as

AdultCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCentral Nervous System NeoplasmsDisease-Free SurvivalDisease ProgressionDNA MethylationFemaleForkhead Transcription FactorsGliomaHumansImmunophenotypingKaplan-Meier EstimateLymphocytes, Tumor-InfiltratingMaleMiddle AgedForkhead Transcription FactorsFOXP3 protein, human

Identifiers

PMID24691423
PMCPMC4021514
OpenAlexW2044685551

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.