Evidence map›Paper›PMID 24691403›Full record

ArticlePloS one2014

Association of childhood chronic physical aggression with a DNA methylation signature in adult human T cells.

Nadine Provençal, Matthew J Suderman, Claire Guillemin, Frank Vitaro, Sylvana M Côté, Michael Hallett, Richard E Tremblay, Moshe Szyf

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.

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  6. Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Nadine ProvençalDepartment of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada; Research Unit on Children's Psycho-Social Maladjustment and Sainte-Justine Hospital Research Center, University of Montreal, Montreal, Canada; Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Quebec, Canada.
Matthew J SudermanDepartment of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada; Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Quebec, Canada; McGill Centre for Bioinformatics, McGill University, Montreal, Quebec, Canada.
Claire GuilleminDepartment of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada; Research Unit on Children's Psycho-Social Maladjustment and Sainte-Justine Hospital Research Center, University of Montreal, Montreal, Canada; Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Quebec, Canada.
Frank VitaroResearch Unit on Children's Psycho-Social Maladjustment and Sainte-Justine Hospital Research Center, University of Montreal, Montreal, Canada; School of Psycho-Education, University of Montreal, Montréal, Quebec, Canada.
Sylvana M CôtéResearch Unit on Children's Psycho-Social Maladjustment and Sainte-Justine Hospital Research Center, University of Montreal, Montreal, Canada; School of Social and Preventive Medicine, University of Montreal, Montréal, Quebec, Canada.
Michael HallettMcGill Centre for Bioinformatics, McGill University, Montreal, Quebec, Canada.
Richard E TremblayResearch Unit on Children's Psycho-Social Maladjustment and Sainte-Justine Hospital Research Center, University of Montreal, Montreal, Canada; Department of Psychology and Pediatrics, University of Montreal, Montreal, Quebec, Canada; School of Public Health, Physiotherapy and Population Sciences, University College Dublin, Dublin, Ireland.
Moshe SzyfDepartment of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada; Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Quebec, Canada.
McGill University · CAResearch Unit on Children's Psychosocial Maladjustment · CAUniversité de Montréal · CA

Funding

Canadian Institutes of Health Research MOP-42411
6 · The paper itself

Abstract

backgroundChronic physical aggression (CPA) is characterized by frequent use of physical aggression from early childhood to adolescence. Observed in approximately 5% of males, CPA is associated with early childhood adverse environments and long-term negative consequences. Alterations in DNA methylation, a covalent modification of DNA that regulates genome function, have been associated with early childhood adversity.

aimsTo test the hypothesis that a trajectory of chronic physical aggression during childhood is associated with a distinct DNA methylation profile during adulthood.

methodsWe analyzed genome-wide promoter DNA methylation profiles of T cells from two groups of adult males assessed annually for frequency of physical aggression between 6 and 15 years of age: a group with CPA and a control group. Methylation profiles covering the promoter regions of 20 000 genes and 400 microRNAs were generated using MeDIP followed by hybridization to microarrays.

resultsIn total, 448 distinct gene promoters were differentially methylated in CPA. Functionally, many of these genes have previously been shown to play a role in aggression and were enriched in biological pathways affected by behavior. Their locations in the genome tended to form clusters spanning millions of bases in the genome.

conclusionsThis study provides evidence of clustered and genome-wide variation in promoter DNA methylation in young adults that associates with a history of chronic physical aggression from 6 to 15 years of age. However, longitudinal studies of methylation during early childhood will be necessary to determine if and how this methylation variation in T cells DNA plays a role in early development of chronic physical aggression.

Indexed as

AdultAggressionCase-Control StudiesChildChromosomes, HumanCluster AnalysisCpG IslandsDNA MethylationFemaleGenome, HumanHumansMalePromoter Regions, GeneticT-Lymphocytes

Identifiers

PMID24691403
PMCPMC3972178
OpenAlexW2080011484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.