ArticleIEEE transactions on medical imaging2014
A method to estimate biomechanics and mechanical properties of optic nerve head tissues from parameters measurable using optical coherence tomography.
Article in IEEE transactions on medical imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Cyclic stretch increases transglutaminase 2-mediated serotonylation of extracellular fibronectin in cultured optic nerve head astrocytes: a pilot study.Matrix biology plus · 2026Article
- Changes in the nonlinear and viscoelastic mechanical properties of the rat lamina cribrosa under chronic high intraocular pressure.Frontiers in bioengineering and biotechnology · 2026Article
- Finite Element Model of the Effect of Optic Nerve Sheath Anisotropy on Ocular Loading During Horizontal Duction.Bioengineering (Basel, Switzerland) · 2025Article
- Mechanical property changes of glial LC and RGC axons in response to high intraocular pressure.Frontiers in bioengineering and biotechnology · 2025Article
- Fibrous finite element modeling of the optic nerve head region.Acta biomaterialia · 2024Article
- Direct measurements of collagen fiber recruitment in the posterior pole of the eye.Acta biomaterialia · 2024Article
- Role of radially aligned scleral collagen fibers in optic nerve head biomechanics.Experimental eye research · 2020Article
- Scleral structure and biomechanics.Progress in retinal and eye research · 2020Review
- Variation of Peripapillary Scleral Shape With Age.Investigative ophthalmology & visual science · 2019Article
- Seeing the Hidden Lamina: Effects of Exsanguination on the Optic Nerve Head.Investigative ophthalmology & visual science · 2018Article
- The effects of graded intraocular pressure challenge on the optic nerve head.Experimental eye research · 2018Article
- Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics.Investigative ophthalmology & visual science · 2018Article
- The connective tissue phenotype of glaucomatous cupping in the monkey eye - Clinical and research implications.Progress in retinal and eye research · 2017Review
- On the behavior of an eye encircled by a scleral buckle.Journal of mathematical biology · 2017Article
- In-vivo effects of intraocular and intracranial pressures on the lamina cribrosa microstructure.PloS one · 2017Article
- What is a typical optic nerve head?Experimental eye research · 2016Article
- Use and Misuse of Laplace's Law in Ophthalmology.Investigative ophthalmology & visual science · 2016Review
- Glaucoma-related Changes in the Mechanical Properties and Collagen Micro-architecture of the Human Sclera.PloS one · 2015Article
- Translating ocular biomechanics into clinical practice: current state and future prospects.Current eye research · 2015Review
- Research progress of in vivo measurement methods of myopia sclera biomechanics.Advances in ophthalmology practice and researchReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Optic nerve head (ONH) tissue properties and biomechanics remain mostly unmeasurable in the experiment. We hypothesized that these can be estimated numerically from ocular parameters measurable in vivo with optical coherence tomography (OCT). Using parametric models representing human ONHs we simulated acute intraocular pressure (IOP) increases (10 mmHg). Statistical models were fit to predict, from OCT-measurable parameters, 15 outputs, including ONH tissue properties, stresses, and deformations. The calculations were repeated adding parameters that have recently been proposed as potentially measurable with OCT. We evaluated the sensitivity of the predictions to variations in the experimental parameters. Excellent fits were obtained to predict all outputs from the experimental parameters, with cross-validated R2s between 0.957 and 0.998. Incorporating the potentially measurable parameters improved fits significantly. Predictions of tissue stiffness were accurate to within 0.66 MPa for the sclera and 0.24 MPa for the lamina cribrosa. Predictions of strains and stresses were accurate to within 0.62% and 4.9 kPa, respectively. Estimates of ONH biomechanics and tissue properties can be obtained quickly from OCT measurements using an applet that we make freely available. These estimates may improve understanding of the eye sensitivity to IOP and assessment of patient risk for development or progression of glaucoma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.