ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015
Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Suppression rather than activation of the integrated stress response (GCN2-ATF4) pathway extends lifespan in the fly.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Novel tRNA Synthetase Inhibitors Increase Healthspan, Lifespan, and Autophagic Flux inBiomolecules · 2026Article
- Emerging roles for integrated stress response signaling in homeostasis.The FEBS journal · 2025Review
- Molecular Mechanisms of Genotype-Dependent Lifespan Variation Mediated by Caloric Restriction: Insight from Wild Yeast Isolates.bioRxiv : the preprint server for biology · 2024Article
- Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors.GeroScience · 2024Article
- Molecular mechanisms of genotype-dependent lifespan variation mediated by caloric restriction: insight from wild yeast isolates.Frontiers in aging · 2024Article
- Multiomics ofInternational journal of molecular sciences · 2023Article
- Modulation ofAutophagy · 2023Article
- Article
- ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1.Nature communications · 2022Article
- Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells.Science advances · 2021Article
- Perspective: Modulating the integrated stress response to slow aging and ameliorate age-related pathology.Nature aging · 2021Article
- Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response.iScience · 2020Article
- Protein synthesis and quality control in aging.Aging · 2018Review
- Recent Advances in the Systems Biology of Aging.Antioxidants & redox signaling · 2018Review
- Article
- The long non-coding RNA Gm10768 activates hepatic gluconeogenesis by sequestering microRNA-214 in mice.The Journal of biological chemistry · 2018Article
- Proteostasis and ageing: insights from long-lived mutant mice.The Journal of physiology · 2017Review
- The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan.Nature communications · 2017Article
- Molecular pathology endpoints useful for aging studies.Ageing research reviews · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Work in yeast has shown that longevity extension induced by nutrient deprivation, altered ribosomal function, or diminished target of rapamycin action requires the activity of GCN4. We hypothesized that increased activity of ATF4, the mammalian equivalent of yeast GCN4, might be characteristic of mutations that extend mouse life span. Fibroblasts from the skin of two such mutants (Snell dwarf and PAPP-A knockout) were found to have higher levels of ATF4 protein and expression of several ATF4 target genes in responses to amino acid withdrawal, cadmium, hydrogen peroxide, and tunicamycin. ATF4 pathways were also elevated in liver of both kinds of long-lived mutant mice. Thus, a connection between ATF4 pathways and longevity may have deep evolutionary roots, and further studies of ATF4 mechanisms may provide insights into the links between cellular stress resistance, protein translation control, and aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.