ArticleMolecules (Basel, Switzerland)2014
Angelica sinensis improves exercise performance and protects against physical fatigue in trained mice.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Quantitative analysis of Chinese herbal medicine for post-stroke fatigue: a meta-analysis and medication pattern study.Frontiers in pharmacology · 2026Pooled it
- Safety and Tolerability of HemoHIM: A Randomized, Placebo-Controlled, Double-Blind, and Parallel Clinical Trial in Healthy Human Volunteers.Journal of microbiology and biotechnology · 2025Trial
- Repressed Exercise-Induced Hepcidin Levels after Danggui Buxue Tang Supplementation in Male Recreational Runners.Nutrients · 2018Trial
- The herbal pair ofFrontiers in nutrition · 2026Article
- A Comparative Study of Two Different Polarity Extracts ofAquaculture nutrition · 2026Article
- Study on anti-fatigue effect and mechanism of iron source combined with Angelica sinensis and Agrimonia pilosa on pigeons under exercise stress.Poultry science · 2025Article
- The Extract ofVeterinary sciences · 2023Article
- KangPiLao decoction modulates cognitive and emotional disorders in rats with central fatigue through the GABA/Glu pathway.Frontiers in pharmacology · 2022Article
- Antioxidant and antifatigue effect of a standardized fraction (HemoHIM) fromPharmaceutical biology · 2021Article
- The Determination of Efficacy of CircuCare on Blood Circulation and Metabolism: An Animal Model Study.Computational and mathematical methods in medicine · 2021Article
- Chinese herbal decoction (Danggui Buxue Tang) supplementation augments physical performance and facilitates physiological adaptations in swimming rats.Pharmaceutical biology · 2020Article
- Integrated biomarker parameters response to the toxic effects of high stocking density, CuSOFish physiology and biochemistry · 2020Article
- Effects ofAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2019Article
- Sasa quelpaertensis leaf extract mitigates fatigue and regulates the transcriptome profile in mice.Genes & genomics · 2019Article
- Decreased fracture incidence with traditional Chinese medicine therapy in patients with osteoporosis: a nationwide population-based cohort study.BMC complementary and alternative medicine · 2019Article
- The effects of ethoxyquin and Angelica sinensis extracts on lipid oxidation in fish feeds and growth, digestive and absorptive capacities and antioxidant status in juvenile red carp (Cyprinus carpio var. xingguonensis): a comparative study.Fish physiology and biochemistry · 2019Article
- Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke.Frontiers in pharmacology · 2019Article
- A Systematic Review on the Effects of Botanicals on Skeletal Muscle Health in Order to Prevent Sarcopenia.Evidence-based complementary and alternative medicine : eCAM · 2016Review
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angelica sinensis (AS) is a well-known medicinal herb and food material with antioxidative and multifunctional pharmacological activities. However, we lack evidence of the effect of AS on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effect of AS on ergogenic and anti-fatigue functions after physiological challenge. Male ICR strain mice were randomly assigned to four groups (n=10 per group) for treatment: (1) sedentary control and vehicle treatment (vehicle control); (2) exercise training with vehicle treatment (exercise control); (3) exercise training with AS treatment at 0.41 g/kg/day (Ex-AS1); and (4) 2.05 g/kg/day (Ex-AS5); both the vehicle and AS were orally administered for 6 weeks. Exercise performance and anti-fatigue function were evaluated by forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after a 15-min swimming exercise. Trend analysis revealed that AS treatments significantly increased endurance swimming time and blood glucose level, and decreased serum lactate, ammonia and CK levels. Liver and muscle glycogen contents were higher for Ex-AS1 and Ex-AS5 groups than the exercise control. Therefore, AS supplementation improved exercise performance and had anti-fatigue properties in mice and may be an effective ergogenic aid in exercise training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.