ArticleInternational journal of molecular sciences2014
Fabrication of calix[4]arene derivative monolayers to control orientation of antibody immobilization.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Surface plasmon resonance biosensors in the last decade: design strategies and improvements using nanomaterials.Mikrochimica acta · 2026Review
- A simple urine test by 3D-plus-3D immunoassay guides preciseBioengineering & translational medicine · 2023Article
- Resorc[4]arene-Modified Gold-Decorated Magnetic Nanoparticles for Immunosensor Development.Bioconjugate chemistry · 2023Article
- Precise and Prompt Analyte Detection via Ordered Orientation of Receptor in WSeNanomaterials (Basel, Switzerland) · 2022Article
- Article
- Sensors Based on Bio and Biomimetic Receptors in Medical Diagnostic, Environment, and Food Analysis.Biosensors · 2018Review
- Site-selective orientated immobilization of antibodies and conjugates for immunodiagnostics development.Methods (San Diego, Calif.) · 2017Review
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Authors and funding
5 authors.
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Abstract
Three calix[4]arene (Cal-4) derivatives which separately contain ethylester (1), carboxylic acid (2), and crownether (3) at the lower rim with a common reactive thiol at the upper rim were synthesized and constructed to self-assembled monolayers (SAMs) on Au films. After spectroscopic characterization of the monolayers, surface coverage and orientation of antibody immobilized on the Cal-4 derivative SAMs were studied by surface plasmon resonance (SPR) technique. Experimental results revealed that the antibody could be immobilized on the Cal-4 derivatives spontaneously. The orientation of absorbed antibody on the Cal-4 derivative SAMs is related to the SAM's dipole moment. The possible orientations of the antibody immobilized on the Cal-4 derivative 1 SAM are lying-on or side-on, while on the Cal-4 derivative 2 and Cal-4 derivative 3 head-on and end-on respectively. These experimental results demonstrate the surface dipole moment of Cal-4 derivative appears to be an important factor to antibody orientation. Cal-4 derivatives are useful in developing site direct protein chips.
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